, that illness was due to the uterus moving around the body like a ..

09/01/2018 · The Wandering Uterus: Politics and the Reproductive Rights of ..

“Magical and Medical Approaches to the Wandering Womb …

Besides the erroneous hypothesis of Ercolani, there are three views as to the origin of the decidual cells known to me, to wit : 1°, they are modified leucocytes (Hennig, Langhans, et al) ; 2°, they arise from the connective tissue cells of the mucosa (Leopold, 36) ; 3°, they are produced by the epithelium (Overlach, 39). The first view is not supported by observation, even by its advocates, and may be dismissed. Overlach' s observations certainly favor the third view, but inasmuch as he has studied only one uterus with pseudo-menstruation from acute phosphorus poisoning, his theory cannot be accepted definitely until verified by further observations on normal uteri. Overlach found in the cervix of the uterus in question, the lining epithelial cells to contain an endogenous brood of small cells, one to fifteen in each parent-cell ; the daughter-cells begin as nuclei, around which there gathers a protoplasmatic body for each. The cells are like the young decidual cells just below, so that the latter may be assumed to have wandered forth from the epithelium. I may recall that in the normal menstruating uterus I find no true decidual cells, and consequently I must regard Overlach' s find as pathological.

27/04/2017 · Revisiting the wandering womb: Oxytocin in endometriosis ..

We propose and evaluate the hypothesis that ..


The mesoderm in the villi is differentiated otherwise than that of the membrane of the chorion. In the youngest stage I have examined there is some of the primitive matrix present in the villi ; and I presume that earlier the whole mesoderm has the same character. In my specimen (three weeks) the change is progressing. I have not succeeded in satisfying myself as to the process of change which takes place, but I think it probably essentially as follows : The cells gradually develop large bodies and acquire a more decided affinity for coloring-matters ; meanwhile vacuoles appear in the matrix, presumably by its modification into a new substance; the vacuoles increase in size and number, transforming the matrix into a network and ultimately causing its total disappearance, leaving the intercellular spaces filled entirely with the new substance, which has come from a metamorphosis of the original matrix; probably this new substance is more or less fluid, since wandering cells are scattered freely through it. Leaving this half-hypothetical history, let us pass on to direct observations. In the placental villi of embryos of four months and older, the mesoderm exists in two principal forms, — adenoid tissue and fibre-cell tissue around the bloodvessels. The adenoid tissue, Cut 21, is that of which the supposed development has just been sketched ; it may be considered as the proper tissue of the villus. It consists of a network of protoplasmic threads, which start from nucleated masses (cells). There are many large meshes, which are partly occupied by the coarsely granular wandering cells, /, /, which are scattered about, and are usually present in large numbers. About the capillaries the network is much more finely spun. Kastschenko, 107, 454, found the wandering cells most abundant near the epithelium, but I have noticed no such peculiarity, except that they do not often enter the dense perivascular tissue ; and as the bloodvessels are centrally situated, the adenoid tissue and the wandering cells in it are of course more peripheral. It seems to me that the leucocytes are distributed more or less evenly throughout the adenoid tissue. I fail to recognize any intercellular substance. The abundance of nuclei deserves special mention. Around all the non-capillary vessels the mesoderm is very different, for it exhibits distinct intercellular substance, with a tendency to fibrillar differentiation in quite a wide zone around the blood-vessels ; in this zone the cells become elongated and irregularly fusiform ; around the larger vessels the cells are grouped in lamina, making the structure similar to that already described in the walls of the vessels of the umbilical cord ; after the perivascular coats acquire a certain thickness, the cells of the inner layers are more elongated, more regularly fusiform, and more closely packed than those of the outer layer ; the transition from the denser to the looser tissue is gradual. We are perhaps entitled to recognize in the denser inner layer the media, in the outer looser layer the adventitia, although neither of the layers has by any means the full histological differentiation characteristic of the like-named layers of the blood-vessels of the adult.

The concept of a pathological wandering womb was later ..


The mesoderm in the villi is differentiated otherwise than that of the membrane of the chorion. In the youngest stage I have examined there is some of the primitive matrix present in the villi ; and I presume that earlier the whole mesoderm has the same character. In my specimen (three weeks) the change is progressing. I have not succeeded in satisfying myself as to the process of change which takes place, but I think it probably essentially as follows : The cells gradually develop large bodies and acquire a more decided affinity for coloring-matters ; meanwhile vacuoles appear in the matrix, presumably by its modification into a new substance; the vacuoles increase in size and number, transforming the matrix into a network and ultimately causing its total disappearance, leaving the intercellular spaces filled entirely with the new substance, which has come from a metamorphosis of the original matrix; probably this new substance is more or less fluid, since wandering cells are scattered freely through it. Leaving this half-hypothetical history, let us pass on to direct observations. In the placental villi of embryos of four months and older, the mesoderm exists in two principal forms, — adenoid tissue and fibre-cell tissue around the bloodvessels. The adenoid tissue, Cut 21, is that of which the supposed development has just been sketched ; it may be considered as the proper tissue of the villus. It consists of a network of protoplasmic threads, which start from nucleated masses (cells). There are many large meshes, which are partly occupied by the coarsely granular wandering cells, /, /, which are scattered about, and are usually present in large numbers. About the capillaries the network is much more finely spun. Kastschenko, 107, 454, found the wandering cells most abundant near the epithelium, but I have noticed no such peculiarity, except that they do not often enter the dense perivascular tissue ; and as the bloodvessels are centrally situated, the adenoid tissue and the wandering cells in it are of course more peripheral. It seems to me that the leucocytes are distributed more or less evenly throughout the adenoid tissue. I fail to recognize any intercellular substance. The abundance of nuclei deserves special mention. Around all the non-capillary vessels the mesoderm is very different, for it exhibits distinct intercellular substance, with a tendency to fibrillar differentiation in quite a wide zone around the blood-vessels ; in this zone the cells become elongated and irregularly fusiform ; around the larger vessels the cells are grouped in lamina, making the structure similar to that already described in the walls of the vessels of the umbilical cord ; after the perivascular coats acquire a certain thickness, the cells of the inner layers are more elongated, more regularly fusiform, and more closely packed than those of the outer layer ; the transition from the denser to the looser tissue is gradual. We are perhaps entitled to recognize in the denser inner layer the media, in the outer looser layer the adventitia, although neither of the layers has by any means the full histological differentiation characteristic of the like-named layers of the blood-vessels of the adult.

Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder