Section I Symposium: Materials and Tribology in Total Hip Replacement

2 cases self-femoral-head transplant and biological total hip replacement healed well.

The Microenvironment around Total Hip Replacement Prostheses

An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane BMC Musculoskelet Disord 2004; 5: 7.].

Cytokines in aseptic loosening of total hip replacement Curr Orthop 1997; 11: 40-7.].

resorption around total hip replacement prosthesis

An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane BMC Musculoskelet Disord 2004; 5: 7.].

Cytokines in aseptic loosening of total hip replacement Curr Orthop 1997; 11: 40-7.,

Periprosthetic osteolysis is a serious complication of total hip replacement (THR) in the medium to long term. Although often asymptomatic, osteolysis can lead to prosthesis loosening and periprosthetic fracture. These complications cause significant morbidity and require complex revision surgery. Here, we review advances in our understanding of the cell and tissue response to particles produced by wear of the articular and non-articular surfaces of prostheses. We discuss the molecular and cellular regulators of osteoclast formation and bone resorptive activity, a better understanding of which may lead to pharmacological treatments for periprosthetic osteolysis. We describe the development of imaging techniques for the detection and measurement of osteolysis around THR prostheses, which enable improved clinical management of patients, provide a means of evaluating outcomes of non-surgical treatments for periprosthetic osteolysis, and assist in pre-operative planning for revision surgery. Finally, there have been advances in the materials used for bearing surfaces to minimise wear, and we review the literature regarding the performance of these new materials to date.

Cytokines in aseptic loosening of total hip replacement Curr Orthop 1997; 11: 40-7.


around loose total hip prosthesis

oral regimen consisting of the combination of (200 mg t.i.d.) and rifampin (900 mg. q.d.) has been studied in a non- comparative trial for S. aureus prosthetic joint infections of the hip (n=10) and knee (n=7) (). Patients with hip infections received oral therapy for five months preoperatively and one month postoperatively with removal of the infected joint. The cure rate was 70% (7/10). Patients with knee infections received oral therapy for six months preoperatively and three months postoperatively with removal of the infected joint. The cure rate was 71% (5/7). Failures with emergence of resistant occurred in 1 patient from each group. In another study of prosthetic joint infections caused by staphylococcal species, patients were randomized to oral (750 mg every 12 hours) plus placebo or ciprofloxacin plus rifampin (450 mg every 12 hours), after receiving an initial two weeks of intravenous therapy following debridement surgery (). This group was a select group limited to patients with stable orthopedic implants and short duration of symptoms (). In an open trial comparing oral rifampin with either or ofloxacin for implant infections, a cure rate of 56% (14/25) was found in both groups, four of whom had the device removed. Two out of eight failures in the rifampin/fusidic acid group were due to , one of which was resistant to rifampin but susceptible to fusidic acid and ofloxacin. Similarly, two out of eight failures in the rifampin/ofloxacin group were due to , both of which were resistant to rifampin (). This experience contrasts with the previous study in which rifampin resistance was not encountered when the combination of rifampin plus ciprofloxacin was given ().

microenvironment around total hip replacement ..

An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane BMC Musculoskelet Disord 2004; 5: 7.].Materials composed of elements near to calcium and carbon in the periodic system are more biocompatible over time than others, because the body is composed mostly of those elements and water [

from loose total hip replacement prosthesis produce ..

An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane BMC Musculoskelet Disord 2004; 5: 7.,