CHEMICAL HAZARD INFORMATION PROFILE DRAFT REPORT Semicarbazide ..
Complexes of tin(IV) and organotin(IV) chlorides with Schiff bases derived from thiocarbohydrazide as Cl2SnL, PhClSnL and R2SnL (R = Ph, Bu, PhCH2, p-MeC6H4, C6H11; L = dianion of 15, R1 = H, Me) were prepared by the reaction of the Schiff bases with the Sn(IV) or organo-Sn(IV) chlorides94.A study of the mode of coordination in the complexes of a number of N- and S-containing ligands with transition metal ions was made, based on the IR data of the shift in the thioamide bands I, II, III and IV in the ligand on complexation.
The reactions of semicarbazide and thiosemicarbazide …
Thus, Thiocarbohydrazides with aliphatic, aromatic or heterocyclic substituents have an antifoggant effect during the 1st, and exert a fogging effect during the 2nd color development of reversal materials so that an overall exposure or chemical fogging is unnecessary 69-71.Weatherability improvers for jet-printing ink compositions and inks contain water-soluble dyes, wetting agents, water, and discoloration inhibitors selected from thioureas, thiosemicarbazides, and thiocarbohydrazides72.
The sheet especially useful in ink-jet recording with a coating of a porous ink-receptive layer containing selected derivatives from thiourea, thiosemicarbazide, and thiocarbohydrazide shows good ink absorption and dye fixability and provides high-quality images showing no discoloration upon storage73.
Semicarbazide hydrochloride - Revolvy
Semicarbazide is a derivative of urea, where one -NH2 group has been replaced with hydrazino (H2NNH-) group resulting in a formula H2NNHC(=O)NH2. Thiosemicarbazide is the thio derivative of semicarbazide where oxygen is replaced with sulfur atom. Thiosemicarbazide derivatives are extensively used in the heterocyclic synthesis. It is widely used in the preparation of many biologically active compounds such as pyrazole, thiazole, triazolethiadiazole and thiadiazine.
Thiosemicarbazone is derived by the condensation reaction between thiosemicarbazide and a carbonyl compound (ketone or aldehyde). Thiosemicarbazones are known to have antiviral, anti-infective and antineoplastic properties through binding to copper or iron in cells. Many of the metal complexes of thiosemicarbazones are reported to possess anti-tumor or anti-cancer activity. Some thiosemicarbazones are reported to have anti-Mycobacterium tuberculosis activity. For a review, on the antiviral activity of their metal complexes, pl. see: Pelosi, G., Antiretroviral activity of thiosemicarbazone metal complexes, J. Med. Chem., 2010, 53(24), 8765-9. The ability of thiosemicarbazones to chelate metal ions has been now recognized as a major factor in their antiproliferative effects. Emerging new uses of thiosemicarbazones as potent anticancer agents is discussed in the review (Kalinowski, DS., Thiosemicarbazones: the new wave in cancer treatment, Future Med. Chem. 2009, 1(6),1143-51.
Letters in Drug Design & Discovery
2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C–O/C–S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.
Thiosemicarbazide is the analogous compound with …
The electronic spectrum of [CrL2]Cl [HL = 4- (o-hydroxybenzamido)thiosemicarbazide] gave 4 bands at 13600, 17420, 27400, and 34500 cm-1 from which Racah interelectronic repulsion parameters B35 and B55 were calculated, which yielded a covalency parameter 0.89102.
SYNTHESIS AND CHARACTERISATION OF …
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