T1 - Solid-phase synthesis of 1,3-oxazolidine derivatives

Hydrolysis of 2-[4-(dimethylamino)styryl]-N-phenyl-1,3-oxazolidine,

Synthesis of 5-Methylene-1,3-oxazolidin-2-ones

Several new chiral oxazolines 41 were prepared conveniently in good to high yields using a two-step synthesis using microwave irradiations under solvent free conditions. This method involves the formation of an optically active amide 40, in situ conversion of the amide into tosylate (OTs) and finally rings closing reaction gives substituted oxazolines 28.

Key Words: Dichloroacetyl oxazolidines; Synthesis; Herbicide safeners; Bioactivity.

New Synthesis of Chiral Oxazolidin-2-ones

ABSTRACT: Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the core structure of many biologically active natural compounds. Oxazoline play a major role in medicinal chemistry. Heterocyclic compounds whose containing oxazoline moiety as core structure reported wide range of biological activities such as antibacterial, antifungal, antimicrobial, antioxidant, antipyretic, anti-HIV, anti malarial, anti tumour, anti viral, anti-inflammatory, CNS stimulant activity etc. Oxazolines synthesized by the reaction of various aromatic substitutes like acids, aldehydes, nitriles, azides etc. Synthetic chemist do great work on the synthesis and application part of oxazolines. In this review we have described various synthetic methodologies and their different biological activities reported by organic synthetic chemist

Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative

An expedient synthesis of the polymer-supported aldehyde 3, as a Garner aldehyde equivalent, is described. Oxazolidine 3 may be obtained through preformation of aldehyde linker 4 in solution and loaded onto amine-terminating resin under peptide-coupling conditions, or alternatively via oxidation of polymer-bound alcohol 14. The integrity of the serine-derived stereocenter is maintained through all steps of the synthesis.

JF - Tetrahedron Letters


Synthesis of a Polymer-Supported Oxazolidine …

1,3-Oxazolidines 9 were synthesized by using a solid support. Regioselective ring opening of resin-bound epoxy ether 3 with ammonium chloride followed by nucleophilic substitution with sodium azide gave azido alcohol 7. Reduction of 7 provided 1-amino-2-alkanol 6, which was treated with various aldehydes and acyl chlorides or isocyanates to afford the corresponding 1,3-oxazolidines immobilized on Wang resin. Oxidative cleavage with DDQ from the solid support yielded 1,3-oxazolidines as a mixture of 10 (cis) and 11 (trans). (C) 2000 Elsevier Science Ltd.

Synthesis of oxazolidine-2,4-diones by a tandem …

INTRODUCTION N-dichloroacetyl-l,3-oxazolidine derivatives have various biological applications1"3, and their bioactivities have been investigated for potential used as herbicide safener4"6.

The Oxazolidines. - Chemical Reviews (ACS …

INTRODUCTION: Oxazolines have been known for many years, but in recent years the chemical literature shown considerable activity in this field. A number of review articles 1, 2 were published about the synthesis, reactions and applications of oxazolines. The literature following publication of those articles indicates a many-fold increase in university and commercial activity involving preparation, reactions, and uses of oxazolines.

Determination of formaldehyde in air as an oxazolidine ..

A survey of the literature indicated that N-dichloroacetyl1,3-oxazolidine increasing the content of glutathione (GSH) and the activities of glutathione-S-transferase (GST) and some herbicide target enzyme to protect the crop from the injury by the herbicides7"9.

One-pot synthesis of oxazolidine-2-thione and …

AB - An efficient two-step synthesis of 1-aryl-2-dimethylamnoethanols 4 is described, consisting of oxazolidine 3 generation from the cycloaddition of an azomethine ylide to an aldehyde, followed by reductive ring-opening.