51444-79-2 | Otilonium Bromide ITS-2 | MolCore

Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.
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Otilonium Bromide | CAS 26095-59-0 | AbMole …

Studies have shown the efficacy of otilonium bromide in IBS patients. Diarrheal symptoms and abdominal pain were significantly improved by otilonium bromide.

Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study.
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Otilonium bromide supplier | CasNO.26095-59-0 - …

Antispasmodics are a heterogeneous group of drugs that reduce smooth muscle contractility of the gut. Antispasmodics can be divided into two groups, based on the mechanism of action. Agents directly affecting intestinal smooth muscle by acting on calcium channels include alverine citrate, otilonium bromide, peppermint oil, pinaverium bromide, and mebeverine. Those with anticholinergic/antimuscarinic properties include butylscopolamine, hyoscine, cimetropium bromide, pirenzepine, dicyclomine, and prifinium bromide. Anticholinergics reduce motility and secretion by blocking the binding of the neurotransmitter acetylcholine to its receptor. These agents can act on other body organs through muscarinic receptors, resulting in adverse effects such as dry mouth, tachycardia, and impaired vision. The agents acting on calcium channels slow colonic transit, improve stool consistency and frequency, and usually do not have the side effects of anticholinergics.

Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome.
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Alverine citrate is an antispasmodic agent modulating smooth muscle activity by inhibiting calcium uptake. In animal studies, alverine was reported to reduce the response of the gastrointestinal tract to mechanical and chemical stimuli. Reduced calcium influx may lead to decreased chemical sensitivity and smooth muscle relaxation. Alverine citrate can suppress both the frequency and amplitude of smooth muscle contractions of the gastrointestinal tract. Thus, it is used for the treatment of IBS, particularly in a combined form with simethicone. Simethicone potentiates the antinociceptive action of alverine. Combined treatment with alverine citrate and simethicone reduces abdominal pain and discomfort in patients with IBS.

Clinical and functional evaluation of the efficacy of otilonium bromide: a multicenter study in Italy.
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Otilonium Bromide - Pharmacodia

Agents directly affecting intestinal smooth muscle by acting on calcium channels include alverine citrate, otilonium bromide, peppermint oil, pinaverium bromide, and mebeverine.

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Thus, it has a selective antispasmodic action on the gastrointestinal tract, particularly on the colon. It not only blocks L-type calcium-channels, but also binds to muscarinic receptors and tachykinin NK2 receptors. Thus, otilonium bromide may have spasmolytic effects and antisecretory action.

Otilonium Bromide, CAS Number: 26095-59-0

Antispasmodics including alverine citrate, mebeverine, otilonium bromide, and pinaverium bromide are used for relieving diarrheal symptoms and abdominal pain.

Otilonium bromide|Octylonium bromide;SP63|CAS …

Pharmacologic agents that can be used for the management of chronic diarrhea include loperamide, 5-HT3 receptor antagonists, diosmectite, cholestyramine, probiotics, antispasmodics, rifaximin, and anti-inflammatory agents ().