Magnetic properties of monodisperse iron oxide nanoparticles

Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive ..

Size-controlled synthesis of monodisperse superparamagnetic iron ..

N2 - Magnetoferritin nanoparticles have been developed as high-relaxivity, functional contrast agents for MRI. Several previous techniques have relied on unloading native ferritin and re-incorporation of iron into the core, often resulting in a polydisperse sample. Here, a simplified technique is developed using commercially available horse spleen apoferritin to create monodisperse magnetoferritin. Iron oxide atoms were incorporated into the protein core via a step-wise Fe(II)Chloride addition to the protein solution under low O 2 conditions; subsequent filtration steps allow for separation of completely filled and superparamagnetic magnetoferritin from the partially filled ferritin. This method yields a monodisperse and homogenous solution of spherical particles with magnetic properties that can be used for molecular magnetic resonance imaging. With a transverse per-iron and per-particle relaxivity of 78 mM-1 sec-1 and 404,045 mM-1 sec-1, respectively, it is possible to detect ∼10 nM nanoparticle concentrations in vivo.

Synthesis and Magneto-Thermal Actuation of Iron Oxide …

AB - Magnetoferritin nanoparticles have been developed as high-relaxivity, functional contrast agents for MRI. Several previous techniques have relied on unloading native ferritin and re-incorporation of iron into the core, often resulting in a polydisperse sample. Here, a simplified technique is developed using commercially available horse spleen apoferritin to create monodisperse magnetoferritin. Iron oxide atoms were incorporated into the protein core via a step-wise Fe(II)Chloride addition to the protein solution under low O 2 conditions; subsequent filtration steps allow for separation of completely filled and superparamagnetic magnetoferritin from the partially filled ferritin. This method yields a monodisperse and homogenous solution of spherical particles with magnetic properties that can be used for molecular magnetic resonance imaging. With a transverse per-iron and per-particle relaxivity of 78 mM-1 sec-1 and 404,045 mM-1 sec-1, respectively, it is possible to detect ∼10 nM nanoparticle concentrations in vivo.

In recent years, multifunctional nanoparticles (NPs) consisting of either metal (e.g. Au), or magnetic NP (e.g. iron oxide) with other fluorescent components such as quantum dots (QDs) or organic dyes have been emerging as versatile candidate systems for cancer diagnosis, therapy, and macromolecule delivery such as micro ribonucleic acid (microRNA). This review intends to highlight the recent advances in the synthesis and application of multifunctional NPs (mainly iron oxide) in theranostics, an area used to combine therapeutics and diagnostics. The recent applications of NPs in miRNA delivery are also reviewed.


Development and use of iron oxide nanoparticles (Part …

Higher temperature may enhance the rate of conversion of manganese acetate to manganese-oleate. However the decomposition temperature of the manganese-oleate complex is close to 220°C (). Hence, taking above factors into consideration, a temperature of 180°C was chosen for the above reaction. Oleic acid is proven to have good ligation properties, stabilizing properties and also environmental friendly.

generating monodisperse iron oxide crystals.

Dickerson, “Comparing Highly Ordered Monolayers of Nanoparticles Fabricated Using Electrophoretic Deposition: Cobalt Ferrite Nanoparticles versus Iron Oxide Nanoparticles”, J.

The synthesis of iron-oxide nanoparticles ..

Sun, “Tuning Electron-Conduction and Spin Transport in Magnetic Iron Oxide Nanoparticle Assemblies via Tetrathiafulvalene-Fused Ligands", ACS Nano, 2015, 9, 12205–12213.
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Controlled synthesis of monodisperse iron oxide ..

Hydrophilic SPIONs for biological application usually consist of an iron oxide core and a surface coating. On one hand, synthesis methods of the iron oxide core, stabilizer and reaction parameters have significant effects on the size and magnetic properties of SPIONs [, -]. On the other hand, surface coating materials, functionalization materials and surface engineering methods significantly affect ultimate size in living fluid, biocompatibility, cell internalization and duration in cells [, , , ]. Therefore, to prepare ideal SPIONs, major factors such as core synthesis, surface coating and functional materials, and surface engineering methods should be carefully considered.