Redox potentials, laccase oxidation, and antilarval ..
These studies suggests that PQ1 might have anti-apoptotic activities in normal cells, in contrast to the role of PQ1 in cancer cells where it has demonstrated to induce apoptosis.
Since substituted di-tert-butyl phenols including MON-0585 ..
As shown in , there is an inverse correlation between laccase catalytic efficiency and oxidation potential of the water-soluble compounds 1 – 8, 34, 35, ABTS, 2-aminophenol, catechol, hydroquinone, and 1,2-phenylenediamine. These results are consistent with previous studies [–]. These compounds show either nearly reversible or quasi-reversible redox properties except 1,2-phenylenediamine. The lower the peak potential for oxidation (i.e. Epa1 in ), the higher the laccase activity is. 1,2-Phenylenediamine shows a very high oxidation potential and thus gives the lowest laccase activity. However, no clear correlation was found between the electrochemical reaction rate and reversibility of the compounds, both of which are reflected by the peak separation redox waves (i.e. ΔEp = Epa − Epc). Compounds 9 – 15, 33, and MON-0585 are insoluble in water, and their oxidation by laccase could not be detected.
Various known laccase substrates such as hydroquinone, catechol, 2-aminophenol, 1,2-phenylenediamine, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 3-amino-4-hydroxybenzoic acid (34), 4-amino-3-hydroxybenzoic acid (35), and our synthesized materials, compounds 1 – 15, 18, 33, and MON-0585 were studied for their redox potentials () and ability to be oxidized by fungal laccase ().