Synthesis of 1-hydroxyethyl-2-alkyl-2-imidazoline and …

The synthesis of 4-{p-[(2-chloroethyl)-(2-hydroxyethyl)-amino]phenyl}butyric acid is reported

Synthesis of 9-[1-(1 -hydroxyethyl)-3 …

T1 - Structure-based design, synthesis, and evaluation of 2′-(2- hydroxyethyl)-2′-deoxyadenosine and the 5′-diphosphate derivative as ribonucleotide reductase inhibitors

T1 - Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4

Hydroxyethyl cellulose for synthesis | VWR

N2 - A procedure is reported for the rapid (≤1 day) and reproducible purification of 2-(1-hydroxyethyl)thiamine (HET) from contaminating thiamine (≤50%) using aqueous cation exchange chromatography. The unhydrated product contains ≤0.2% thiamine on the basis of its 1H NMR spectrum, visualization on silica gel TLC by fluorescence quenching after development in 60% aqueous ethanol, and the failure to observe the hydrolysis of thiamine using an iodine trapping assay under conditions where hydrolysis of ≤0.2% contaminating thiamine would have been detected. This purification procedure is also applicable to the resolved R and S stereoisomers of HET. Several literature procedures for the synthesis and purification of racemic HET are discussed and critically evaluated.

AB - A procedure is reported for the rapid (≤1 day) and reproducible purification of 2-(1-hydroxyethyl)thiamine (HET) from contaminating thiamine (≤50%) using aqueous cation exchange chromatography. The unhydrated product contains ≤0.2% thiamine on the basis of its 1H NMR spectrum, visualization on silica gel TLC by fluorescence quenching after development in 60% aqueous ethanol, and the failure to observe the hydrolysis of thiamine using an iodine trapping assay under conditions where hydrolysis of ≤0.2% contaminating thiamine would have been detected. This purification procedure is also applicable to the resolved R and S stereoisomers of HET. Several literature procedures for the synthesis and purification of racemic HET are discussed and critically evaluated.


CAS No.95-38-5,1H-Imidazole-1-ethanol,2-(8 …

Hydrogels are hydrophilic polymers that can swell and absorb water without dissolving, provided that chemical or physical crosslinks exist among the macromolecular chains. The hydrogel can be derived from synthetic and natural polymers, the latter having desirable properties such as biocompatibility and biodegradation that do not produce adverse and reproductive and developmental effects. The aim of this study was to synthesize a physical hydrogel from a water-soluble cellulose derivative and a solution of 6 wt% sodium hydroxide/5 wt% thiourea. Physical hydrogels (also called self-assembling hydrogels) are formed when macromolecules self-assemble through non-covalent, secondary molecular interactions such as hydrophobic, electrostatic, and H-bonding. Hydroxyethyl cellulose, hydroxypropyl cellulose, and microcrystalline cellulose were used in this study. A hydrogel made from hydroxyethyl cellulose containing weight percentages of 5, 7.5, 10, and 12.5 wt% in the sodium hydroxide/thiourea solution. Hydroxypropyl cellulose only formed a cloudy yellow solution while microcrystalline cellulose did not dissolve at all in the solution. The hydroxyethyl cellulose/ sodium hydroxide/thiourea hydrogels were then characterized according to its functional groups present, physical structure, and mechanical properties, and biocompatibility.

TIANFU-CHEM 95-38-5 N-B-HYDROXYETHYL OLEYL IMIDAZOLINE

AB - Analysis of the recently solved X-ray crystal structures of Saccharomyces cerevisiae ribonucleotide reductase I (ScRnr1) in complex with effectors and substrates led to the discovery of a conserved water molecule located at the active site that interacted with the 2′-hydroxy group of the nucleoside ribose. In this study 2′-(2-hydroxyethyl)-2′-deoxyadenosine 1 and the 5′- diphosphate derivative 2 were designed and synthesized to see if the conserved water molecule could be displaced by a hydroxymethylene group, to generate novel RNR inhibitors as potential antitumor agents. Herein we report the synthesis of analogues 1 and 2, and the co-crystal structure of adenosine diphosphate analogue 2 bound to ScRnr1, which shows the conserved water molecule is displaced as hypothesized.

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To explore environmentally benign solvents for absorbing SO2, a series of hydroxyl ammonium ionic liquids (ILs) was synthesized and characterized, and the solubilities of SO2 in these synthesized ILs were determined. It was found that the solubilities of SO2 in these ILs at ambient pressure are quite high, for example, the solubility of SO2 in tri-(2-hydroxyethyl)ammonium lactate is 0.4957 mole fraction and decreases sharply as temperature increase. The absorption and desorption are practically reversible in the synthesized ILs. Comparing with the conventional absorbents such as calcium carbonate (CaCO3), calcium oxide (CaO), and sodium hydroxide (NaOH), the synthesized ILs show two advantages: one is that the ILs can be recycled and repeatedly used, another is that the absorbed SO2 can be reversibly released and recovered as a sulfur resource.