Total synthesis of honokiol by selective samarium …

Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer.

A concise synthesis of honokiol, Tetrahedron | DeepDyve

, , , , , , , and (2010) Synthesis, structural andin vitrostudies of well-dispersed monomethoxy-poly(ethylene glycol)–honokiol conjugate micelles. , 5(6), 065006.

Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer.

SYNTHESIS OF HONOKIOL - Colgate-Palmolive Company

Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association
with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional
activity.

Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model.

Since recent studies showed that activation ofKISS1/KISS1R signaling by kisspeptin treatment decreases themotility and invasive capacity of conventional RCC, andoverexpression of KISS1 inhibits invasion of RCC cells Caki-1(,), we confirmed the significantupregulation of and in the 786-0 cellstreated with honokiol by qRT-PCR (). In accordance with the change in mRNA, western blotanalysis showed that honokiol stimulates expression of KISS1 andKISS1R in the 786-0 cells dose-dependently at the protein level().

The synthesis of LTC4 and LTB4 from AA in RBL-1 cell lysates in the presence of Ca2+ was inhibited by honokiol.


Synthesis Of Honokiol (Trustees Of University Of …

Hahm ER, Sakao K and Singh SV: Honokiolactivates reactive oxygen species-mediated cytoprotective autophagyin human prostate cancer cells. Prostate. 74:1209–1221. 2014. : :

A concise synthesis of 4′- O-methyl honokiol | ross …

Tian W, Deng Y, Li L, He H, Sun J and XuD: Honokiol synergizes chemotherapy drugs in multidrug resistantbreast cancer cells via enhanced apoptosis and additionalprogrammed necrotic death. Int J Oncol. 42:721–732. 2013.

Synthesis of Deuterated Analogs of Honokiol - MDPI

Lai YJ, Lin CI, Wang CL and Chao JI:Expression of survivin and p53 modulates honokiol-induced apoptosisin colorectal cancer cells. J Cell Biochem. 115:1888–1899.2014.

Honokiol, from magnolia bark, shuts down cancer cells …

Joo YN, Eun SY, Park SW, Lee JH, Chang KCand Kim HJ: Honokiol inhibits U87MG human glioblastoma cellinvasion through endothelial cells by regulating membranepermeability and the epithelial-mesenchymal transition. Int JOncol. 44:187–194. 2014.

Structural Modification of Honokiol, a Biphenyl …

Kim DW, Ko SM, Jeon YJ, Noh YW, Choi NJ,Cho SD, Moon HS, Cho YS, Shin JC, Park SM, et al:Anti-proliferative effect of honokiol in oral squamous cancerthrough the regulation of specificity protein 1. Int J Oncol.43:1103–1110. 2013.

Informação relevante para Honokiol aqui

In summary, our results indicate that activation ofKISS1/KISS1R signaling by honokiol decreases the invasiveness andcolonized capacity of highly metastatic RCC cells. Furthermore, weconfirmed that honokiol stimulated the expression of TIMP4dose-dependently (data not shown). It is in accordance with thefinding that metastin suppresses the motility and invasive abilityof RCC cells which possess KISS1R through the downregulation ofMMP-2 (). As emerging studiesshow that KISS1R activates a series of signaling molecules such asprotein kinase C (PKC), extra-cellular signal-regulated kinases 1and 2 (ERK1/2), p38, and phosphatidylinositol-3-kinase (PI3K)(), further studies are inprogress to investigate the specific mechanism of honokiol, whichmay have the potential for use as a natural agent against RCCmetastasis.