Sodium diethyldithiocarbamate - Wikipedia

Wego is an importer of Zinc Diethyldithiocarbamate to numerous countries around the world.

DIETHYLDITHIOCARBAMATE | Sigma-Aldrich

In exponential-phase Chinese-hamster cells, 0.1 mM-diethyldithiocarbamate (DDC) afforded greater than 1 log survival protection to cultures treated before and during exposure to 1 mM-H2O2. Both DDC and H2O2 treatment stimulated the activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, within 4 h of exposure. DDC, and to a lesser degree H2O2, also stimulated the activity of spermidine N1-acetyltransferase (SAT), the rate-limiting enzyme in polyamine catabolism. The increase in SAT activity, after exposure to DDC or another stress (heat shock), was inhibited in cells depleted of putrescine and spermidine by α-difluoromethylornithine (DFMO), the enzyme-activated suicide inhibitor of ODC. Pretreatment with DFMO or heat shock also induced resistance to H2O2 cytotoxicity. Since SAT activity is low in resting cells, yet stimulation of enzyme activity depends on endogenous spermidine pools, these results suggest that the expression of SAT activity occurs by a mechanism involving a stress-dependent displacement of spermidine into a new intracellular compartment. The stimulation of ODC and SAT activities does not appear to be a necessary component of the mechanism by which DDC protects cells from H2O2 cytotoxicity, although spermidine displacement may be a common facet of the cellular response to stress.

Structures of12-O-tetradecanoylphorbol-13-acetate (TPA) anddiethyldithiocarbamate (DDTC).

Search results for DIETHYLDITHIOCARBAMATE at Sigma-Aldrich ..

N2 - In exponential-phase Chinese-hamster cells, 0.1 mM-diethyldithiocarbamate (DDC) afforded greater than 1 log survival protection to cultures treated before and during exposure to 1 mM-H2O2. Both DDC and H2O2 treatment stimulated the activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, within 4 h of exposure. DDC, and to a lesser degree H2O2, also stimulated the activity of spermidine N1-acetyltransferase (SAT), the rate-limiting enzyme in polyamine catabolism. The increase in SAT activity, after exposure to DDC or another stress (heat shock), was inhibited in cells depleted of putrescine and spermidine by α-difluoromethylornithine (DFMO), the enzyme-activated suicide inhibitor of ODC. Pretreatment with DFMO or heat shock also induced resistance to H2O2 cytotoxicity. Since SAT activity is low in resting cells, yet stimulation of enzyme activity depends on endogenous spermidine pools, these results suggest that the expression of SAT activity occurs by a mechanism involving a stress-dependent displacement of spermidine into a new intracellular compartment. The stimulation of ODC and SAT activities does not appear to be a necessary component of the mechanism by which DDC protects cells from H2O2 cytotoxicity, although spermidine displacement may be a common facet of the cellular response to stress.

Copper Diethyldithiocarbamate as an Activator of Nrf2 in Cultured Vascular Endothelial Cells

T1 - Luminescent iridium(I) diethyldithiocarbamate complexes: Synthesis, structure, and reactivity including stereoselective hydrogen oxidative addition


Synthesis of N,N-diethyldithiocarbamate functionalized …

Effect of12-O-tetradecanoylphorbol-13-acetate (TPA) and/ordieth-yldithiocarbamate (DDTC) on the level of Bcl-2 in PANC-1cells. PANC-1 cells were seeded at a density of 1×105cells/ml in medium and incubated for 24 h. The cells were thentreated with TPA or DDTC alone or in combination for 48 h. Bcl-2expression was measured by western blot analysis using ananti-Bcl-2 antibody (05-729; Millipore Corp.).

Sodium diethyldithiocarbamate trihydrate | VWR

Abstract. The synthesis of tris(diethyldithiocarbamato) cobalt (III) by the reaction of sodium diethyldithiocarbamate and cobaltous chloride is described. The recovered crystals of the cobalt complex are characterized by magnetic susceptibility, IR and NMR spectroscopy, and cyclic voltammetry.

Abstract Zinc diethyldithiocarbamate, ..

Effect of treatment12-O-tetradecanoylphorbol-13-acetate (TPA) ordiethyldithiocarbamate (DDTC) alone or in combination on theexpression of proliferating cell nuclear antigen (PCNA) in PANC-1tumors. Immunohistochemistry with a PCNA antibody was performed onthe paraffin-embedded sections of PANC-1 tumors collected from themice following treatment as described in Fig. 5. Representative micrographs ofPCNA immunostaining in tumors from the (A) control, (B)TPA-treated, (C) DDTC-treated and (D) TPA + DDTC-treated groups areshown. PCNA positive cells were determined using a microscope(Nikon Optiphot) and (E) expressed as a percentage of PCNA-positivecells. Each value represents the mean ± SE. *P

Copper Diethyldithiocarbamate | AMERICAN ELEMENTS

Lipophilic agents (such as diethyldithiocarbamate (DDC) and triethylenetetramine dihydrochloride (TETA)) are more able to penetrate cell membranes with potential redistribution of nickel to lipid rich tissues such as the liver and brain (Misra et al, 1987).