Synthesis and Application of Glycopeptide and Glycoprotein Mimetics.

T1 - Synthesis and characterization of a 14-membered polyketide lactone

Recent Advances in the Synthesis of Well-Defined Glycopolymers.

A., Expedient synthesis of 1,2,3-triazole-fused tetracyclic compounds by intramolecular Huisgen (click) reactions on carbohydrate-derived azido-alkynes.

Sonication-Assisted Library Synthesis of Oxazolidinone-Carbohydrate Conjugates.

Synthesis of Functionalized Bisphosphonates via Click Chemistry.

The metabolic options open to lactones fused to alicyclic rings (Nos 1161–1166) include excretion as the open-chain hydroxycarboxylic acid derivative, hydroxylation of ring alkyl substituents producing polar metabolites that may be excreted (Madyastha & Raj, 1993), or oxidative degradation of the carboxylic acid side-chain to yield polar alicyclic or aromatic carboxylic acids that are excreted unchanged or in conjugated form (Brewster et al., 1977a).

Metabolic pathways available to aromatic fused-ring lactones (Nos 1167–1172) include excretion as the glycine or glutamine conjugates of the open-chain hydroxycarboxylic acid derivative, or oxidation or reduction of the side-chain and subsequent excretion as the glucuronic acid conjugate (Ambrose et al., 1933; James et al., 1972).

Synthesis of a Benzolactone Collection using Click Chemistry.

Binding interactions of nucleophiles with the galactosylated enzyme intermediate makes major contributions to the formation of new & beta‐glycosides during lactose conversion

Modular Synthesis of ABC Type Block Copolymers by "Click" Chemistry.

Advances in the Synthesis of 7-Deazapurine - Pyrrolo[2,3-]pyrimidine - 2'-Deoxyribonucleosides Including D- and L-Enantiomers, Fluoro Derivatives and 2',3'-Dideoxyribonucleosides.

Synthesis of Cyclo-PMMA via Click Chemistry Combined with ATRP.

Preparation, Characterization, and Application of Poly(vinyl alcohol)-graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid-Phase Synthesis.

Synthesis of Lanthanide(III) Chelates by Using 'Click' Chemistry.

AB - A short approach for the synthesis of 3,4-fused γ-lactone-γ-lactam bicyclic systems (1) in diastereomeric mixtures from chiral D-alanine methyl ester hydrochloride is described. The key step towards lactonisation is the reduction of the carbonyl ketone of the 5R-configured 3,5-dimethylpyrrolidine-2,4-dione diastereomers (8) via sodium borohydride in the presence of hydrochloric acid. With the presence of ethyl acetyl functionality at C3-position, ester hydrolysis of 8 occurred concomitantly with keto reduction leading to lactonisation and eventually affording the anticipated (3S,4S,5R), (3R,4R,5R), (3R,4S,5R) and (3S,4R,5R) bicyclic moieties. The formation of the fused systems was confirmed by mass spectroscopy (MS) and nuclear magnetic resonance (NMR) analyses.

Synthesis of Ferrocene-containing Polyacetylenes by Click Chemistry.

One-Pot Synthesis of 1,2,3-Triazoles from Benzyl and Alkyl Halides, Sodium Azide and Alkynes in Water under Transition-Metal-Catalyst Free Reaction Conditions.

Design and Synthesis of Triazole-Based Peptide Dendrimers.

Combination of Ring-Opening Polymerization and "Click" Chemistry for the Synthesis of an Amphiphilic Tadpole-Shaped Poly(ε-Caprolactone) Grafted by PEO.