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Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for ..
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PDF Downloads : Oriental Journal of Chemistry

Synthesis of 8-Acetyl-7-alkoxy-4-methylcoumarin (IIIa-c): General Procedures: The 7-hydroxy Compound II (2.18 g., 0.010 mol) was stirred in dry acetone with anhydrous K2CO3 (1.5 g., 0.011 mol) for one hour, then the appropriate alkyl halide (ethyl iodide for IIIa, allyl bromide for IIIb, butyl bromide for IIIc) (0.050 mol) was added to the solution. The reaction mixture was refluxed for 8 h, concentrated and poured onto ice cold water. The solid formed was filtered and recrystallized from ethanol.

11/12/2013 · Synthesis of nitrogen heterocycles underlain by application of 3-(4-Acetyl[phenyl)-2H-coumarin
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veratraldehyde, 120-14-9 - The Good Scents Company

The design and synthesis of coumarin derivatives have attracted considerableattention because of their diverse pharmaceutical applications, includingantivirus, anti-HIV and anti-neoplasm activities (Cherng ,2008;Nawrot-Modranka , 2007; Nakagawa-Goto , 2007). In2008, Zhang andco-workers described the preparation of3-(-methoxyphenyl)-4-hydroxymethyl-6-bromo-7-hydroxycoumarinco-crystallized from methanol (Jiang , 2008). It is wellknownthat variations in substituent groups can alter the biological properties andwe have therefore synthesized the title coumarin derivative and report itsstructure here.

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Treatment of 4a with phenacyl bromide and/or 3-(2-bromoacetyl)benzocoumarin (8) gave the corresponding hydrazonothiazole derivatives (9a,b) respectively (figure 2).

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The L-Arginine-Nitric Oxide Pathway — NEJM

Synthesis of 8-Acetyl-7-alkoxy-4-methylcoumarin (IIIa-c): General Procedures: The 7-hydroxy Compound II (2.18 g., 0.010 mol) was stirred in dry acetone with anhydrous K2CO3 (1.5 g., 0.011 mol) for one hour, then the appropriate alkyl halide (ethyl iodide for IIIa, allyl bromide for IIIb, butyl bromide for IIIc) (0.050 mol) was added to the solution. The reaction mixture was refluxed for 8 h, concentrated and poured onto ice cold water. The solid formed was filtered and recrystallized from ethanol.

30/12/1993 · Review Article

The 4-(4′-acetyl-3′-hydroxy-phenoxymethyl)-coumarin 3 were synthesised by the reaction of 4-bromo methyl coumarin with 2, 4-dihydroxy acetophenones, were found to less active.

The L-Arginine-Nitric Oxide Pathway

In the title coumarin derivative, the C1–C5/C11 and O2/C4/C5/C7C9 rings areinclined to one another at an angle of 0.77 (4)°. The C10 and O4 atoms of thehydroxymethyl and the O1 atom of the hydroxyl substituent all lie close to theplane of the ring system with a maximum deviation of 0.055 (1) Å for O4. Bondlengths and angles observed here are closely similar to those found for3-(-methoxyphenyl)-4-hydroxymethyl-6-bromo-7-hydroxycoumarin (Jiang, 2008). In the crystal, adjacent molecules are aggregatedinto athree-dimensional supramolecular network by O—H···O hydrogen bonds (Table 1and Fig. 2).

Salvador Moncada, and Annie Higgs

In continuation of our interest in developing novel synthetic methodologies, particularly carbon-carbon, carbon-heteroatom bond formations to synthesize pharmaceutically relevant heterocycles [], we have very recently reported SO42-/SnO2-catalyzed C3-alkylation of 4-hydroxycoumarin with secondary benzyl alcohols and O-alkylation with O-acetyl compounds [].

Bioorganic & Medicinal Chemistry Letters | Vol 20, Iss …

Synthesis of thiazolidine-4-ones (XIV-XVII): General procedures: The thiosemicarbazones V-VIII (0.005 mol) were reacted with diethyl bromo malonate (0.00505 mol, 1.207 g) in freshly fused sodium acetate (0.00505 mol, 0.41400 g) and 30 ml ethanol. The solution was refluxed for 8 h, concentrated, and diluted with ice cold water. A crystalline solid was separated, collected, and recrystallized from ethanol.