1,3-propanediol, or a derivative thereof, is used

 2-Amino-2-methyl-1,3-propanediol

2-Methyl-1,3-propanediol 2163-42-0 | TCI America

Devi, T. S. R.; Kumar, J. S.; Ramkumaar, G. R. DFT simulations and vibrational spectra of 2-amino-2-methyl-1,3-propanediol. Spectrochim. Acta, Part A 2014, 133, 214-222.Mekala, P.; Kamisetty, V.; Chien, W. M.; Shi, R.; Chandra, D.; Sangwai, J.; Talekar, A.; Mishra, A. Thermodynamic modeling of binary phase diagram of 2-amino-2-methyl-1,3-propanediol and TRIS(hydroxymethyl)aminomethane system with experimental verification. Calphad 2015, 50, 126-133.

2-methyl-1,3-propanediol - Brief Profile - ECHA

Devi, T. S. R.; Kumar, J. S.; Ramkumaar, G. R. DFT simulations and vibrational spectra of 2-amino-2-methyl-1,3-propanediol. Spectrochim. Acta, Part A 2014, 133, 214-222.

Mekala, P.; Kamisetty, V.; Chien, W. M.; Shi, R.; Chandra, D.; Sangwai, J.; Talekar, A.; Mishra, A. Thermodynamic modeling of binary phase diagram of 2-amino-2-methyl-1,3-propanediol and TRIS(hydroxymethyl)aminomethane system with experimental verification. Calphad 2015, 50, 126-133.


2-METHYL-1,3-PROPANEDIOL CAS#: 2163-42-0

AB - In a route towards the enantiomerically pure 2-methylpropane-1,3-diol mono(p-methoxybenzyl ether), which is an important starting material for natural product synthesis, a kinetic resolution approach by means of lipase-catalyzed hydrolysis as well as acylation has been elaborated. Candida antarctica lipase-catalyzed hydrolysis of the corresponding racemic acetate proceeded with high enantioselectivity (E 35). During the studies, a curious phenomenon was observed, namely, that the enantioselectivity gradually declined accompanying the progress of the hydrolysis. This was due to inhibition of the enzyme-catalyzed reaction caused by the accumulation of the resultant alcohol. The rate of reaction of the more reactive enantiomer became lower. This situation prompted a new process, which would minimize the contamination of the undesired enantiomer, prior to the enzyme-catalyzed hydrolysis. This was successfully achieved with the aid of another Pseudomonas cepacia lipase-catalyzed desymmetrization, taking advantage of the prochiral nature of the starting material, 2-methyl-1,3-propanediol, and the subsequent p-methoxybenzylation under mild conditions.