1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine - OR13592 - …

Odorless Cooling Threshold - 0.02-0.06 ppm 4-methyl-3-(1-pyrrolidinyl)-2[5H]-furanone

65-71-4 | 5-methyl-1,2,3,4-tetrahydropyrimidine-2,4 …

Lindsley CW, Zhao Z, Leister WH, RobinsonRG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, HuberHE, et al: Allosteric Akt (PKB) inhibitors: Discovery and SAR ofisozyme selective inhibitors. Bioorg Med Chem Lett. 15:761–764.2005. : :

Synthesis of Ethyl-6-methyl-2-oxo-4-substituted phenyl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate (1a-1h)

1,5-Diazabicyclo[4.3.0]non-5-ene CAS 3001-72-7 | 803603

IR (KBr) 1647 cm-1 (amide C=O), 3247 cm-1 (-NH).1H NMR (DMSO-d6) δ 2.25 (s, 3H, dihydropyridyl-CH3); 4.0 (s, 2H, NH2);5.1(d,1H,-NH);7.22-7.5(m, 4H, Ar-H); 7.77 (s, 2H, 3-NH/CH); 9.25 (s, 1H, 1-NH), Mass (FAB):251(M+,9%), 186(Base peak 100%).

Synthesis of 6 – Methyl-2-oxo – 4 –substituted – 5 – ( 5- phenyl -1, 3, 4 – oxadiazol -2- yl) -1, 2, 3, 4-tetrahydropyrimidine-2(1H)-one (3a-3h)


Sigma-Aldrich Online Catalog Product List: Chiral Resolving Reagents

1H-NMR: (400MHz, CDCl3), δ ppm 10.59, 9.78, 9.56, 9.32, 9.11, 7.64, 7.74, 7.62, 7.05, 7.03, 6.94, 6.92, 6.70, 6.69, 5.51, 5.06, 3.97, 3.95, 3.47, 2.50, 2.24, 2.07, 1.90, 1.10, 1.08.

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Mohideen et al.,60 synthesized Ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetra hydro pyrimidine-5-carboxylate by grounding a mixture of benzaldehyde (0.106 g, 1 mmol), ethyl acetoacetate (0.130 g, 1 mmol) and urea (0.070 g, 1.17 mmol) with four drops of ortho phosphoric acid for about 30 minutes. The reaction mixture was cooled for 15 minutes and poured into a beaker containing 50 ml of cold water. The precipitate obtained was filtered, washed with water and ethanol to get white solid (0.26 g, 92% yield; mp 203–204). Physiologically active tetrapyrimidinones were successfully prepared by Biginelli reaction by grinding aryl aldehydes, ethylacetoacetate and urea/ thiourea in presence of p-toluenesulphonic acid at room temperature.28

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IR: Characteristic IR (KBr) bands found at: 3510.63, 3150.20, 1674.20, 1596.10, 1452.33, 831.42, 776.55, 707.62, 646.66 (νmax/cm-1).

Sigma-Aldrich Online Catalog Product List: C12 ..

The standard drugs and synthesized compounds were dissolved in minimum quantity of Dimethyl Formamide (DMF) and the volume is adjusted with distilled water to get 50μg/ml and 100μg/ml concentrations. Procaine penicillin and streptomycin are used as standard drugs. These plates were placed in a refrigerator at 8-10°C for 2hrs for proper diffusion of drug in to the media. After cold incubation, the petri plates were transferred to incubator and maintained at 370±20 C for 18-24 hours. After the incubation period, the petriplates were observed for antimicrobial activity by measuring zone of inhibition using venire scale. The results of the synthesized compounds were compared with standard drugs. (Table 2)