Ed., Pergamon Press, Oxford, England, 1991, 451-512.

T1 - A Facile Synthesis of Novel Bis-(indolyl)-1,3,4-oxadiazoles as Potent Cytotoxic Agents

IR (KBr): 3572 (OH), 3323 (N-H), 2978 (C-H), 1664 (C=N), 1591 (C=C).

Teaching and Research Experience: 1. AIMST University, Malaysia, Assoc. Professor (Jan 2009-till date).
2. Farooqia College of Pharmacy, India, Assistant Professor (July 2008-Dec 2008)
3. Bharathi College of Pharmacy, India, Lecturer (Jan 2007-July 2007)
4. Farooqia College of Pharmacy, India, Lecturer (Jan 2002-Jan 2007)
5. KMR College of Pharmacy, India, Lecturer (Jan 1989-Jun 1991)

Mass (m/z): 346 (M+), 211, 135, 107.

With 285 employees, a consolidated turnover of 335 million Swiss Francs in 2015, and more than 15,000 active customers, the Group ranks among the top 500 companies in Switzerland.

Courses Taught (AIMST University): 1. Applied Therapeutics.
2. Hospital Pharmacy and Hospital Pharmacy training.
3. Clinical Pharmacy and Clinical Pharmacy training.
4. Community Pharmacy and Community Pharmacy training.
5. Geriatric Pharmacy.
6. Drug Modeling.
7. Drug Abuse and Society.
8. Pharmacy Practice.

IR (KBr): 3574 (OH), 3306 (N-H), 2960 (C-H), 1650 (C=N), 1571 (C=C).

The bioisosteres, 1,3,4-oxadiazole 14 and 1,3,4-thiadiazole 16 were prepared from the reaction of a common precursor diacylhydrazine 13 with thionyl chloride and Lawesson′s reagent, respectively.

IR (KBr): 3569 (OH), 3336 (N-H), 2976 (C-H), 1645 (C=N), 1574 (C=C).

The anticancer studies on the synthesized compounds revealed that presence of a cyclopentyloxy or n -butyloxy on the C-3 aryl ring and piperdin-4-yl or trichloromethyl at the C-5 position of 1,2,4-oxadiazole is essential for good activity.

IR (KBr): 3568 (OH), 3378 (N-H), 2966 (C-H), 1664 (C=N), 1573 (C=C).

A Convenient Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles via 1,3-Dipolar Cycloaddition/Coupling of Alkynes, Phenylboronic Acids, and Sodium Azide Catalyzed by Cu(I)/Cu(II).

Mass (m/z): 247 (M+), 175, 135, 107.

The structure of the compounds 4b, 4c, 4f, 4i was further supported by its mass spectral data, which showed molecular ion peak M+ respectively at m/z 346, at m/z 301, at m/z 281, at m/z 247,corresponding to the molecular formula respectively C15H12N3O2Cl3Br 135 and 107, at m/z 135 and 107, at m/z 175, 135 and 107., C15H12N3O2Cl, C16H15N3O2, C13H17N3O2. Further peaks of 4b, 4c, 4f, 4i were observed respectively at m/z 211, 135 and 107, at m/z 166.

Colloid Interface Sci. 2007, , 491-496.

The CH3-CH2CH2 protons of n-butyl group of 4i were merged together and obtained as a multiplet at δ 1.16-1.22. The NH-CH2 protons of n-butyl group was obtained as a triplet at δ 3.74.

Table 2: Anti-inflammatory Activity of 1,3,4-Oxadiazole Derivatives

The purity of the compounds was checked by TLC and its characterization on the basis of IR, NMR and Mass spectral data. The IR spectrum of the compound (4a-i) showed peaks at 3580-3560 cm-1, OH stretching; 3382-3294 cm-1, NH stretching; 2988-2960 cm-1, CH stretching; 1670-1630 cm-1, C=N stretching and 1591-1560 cm-1, C=C stretching vibrations of aromatic rings.