Amerson 4-gidrazino-1,2,5-oxadiazol-3-carboxylic acid

(a) Amerson 4-N-methylamino-1,2,5-oxadiazol-3-carboxylic acid ((R=CH3, R'=H)
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19703-92-5 5-Methyl-1,2,4-oxadiazole-3-carboxylic Acid CAS ..

It is quite obvious that the present invention is not limited to the above embodiments, and other variants are possible within the scope of the invention (which is limited by the claims). The following Examples are given for better understanding of the present invention and in no way limit its scope. In some examples, the techniques of synthesis of certain compounds required for the synthesis of the corresponding 4-R-substituted americanov 1,2,5-oxadiazol-3-carboxylic acid, some examples are also given to illustrate some of the synthetic capabilities obtained according to the proposed method of synthesis of americanov 4-R-1,2,5-oxadiazol-3-carboxylic acid, the synthesis of which at the present time in other ways is not known. Specialists in the art should �animate, that the proposed methods can be made various changes that do not alter the scope and essence of the present invention. All publications mentioned in the present description, is available at level specialists in the field of technology to which belongs the present invention. The optimal timing of reactions, shown in the Examples, can be defined by traditional chromatographic methods of monitoring the progress of the reaction. The choice of solvent is generally not critical, if the applied solvent inert to the ongoing reaction and dissolves the reagents are sufficient for the reaction.

b) Amerson 4-N,N-dimethylamino-1,2,5-oxadiazol-3-carboxylic acid ((R=R'=CH3)
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4-Amino-1,2,5-oxadiazole-3-carboxylic acid | CAS …

Ways to get amerzone 4-R-derivatives of 1,2,5-oxadiazol-3-carboxylic acid reaction of the disclosure 1,2,4-oxadiazole cycle not found in the literature.

C) Amerson 4-T-morpholino-1,2,5-oxadiazol-3-carboxylic acid ((R,R'=(C2N4)2O))
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SUBSTANCE: invention relates to the method of production of a heterocyclic compound, namely 3,4-bis(3-aminofurazan-4-yl)-furazan of the formula consisting in successive performance of recovery of furoxane (1,2,5-oxadiazol-2-oxide) cycle of compound 3,4-bis(3-aminofurazan-4-yl)furoxane to dioxime 1,2-bis-(4-aminofurazan-3-yl)-ethane-1,2-dione (3) with hydrazine or hydrogen in presence of a recovery catalyst containing metals of the platinum group: palladium, platinum, deposited onto standard carriers, selected from the following: for instance, activated carbon, carbon soot, barium sulfate, aluminium oxide, silica gel or skeleton Raney nickel with subsequent dehydration of the produced dioxime by dehydration agents, namely, action of anhydrides of carbonic acids, chloroanhydrides of inorganic acids, to 3,4-bis(3-aminofurazan-4-yl)-furazan (1) or its N,N'-diacyl derivative.

Amerson 4,4'-(ethane-1,2-diyldiamine)bis(1,2,5-oxadiazol-3-carboxylic acid)
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Synthesis of N -Heterocycles - Organic chemistry

Chemistry: Nicotinic acid (I) on treatment with ethanol in presence of Conc. Sulphuric acid affords pyridine- 3- carboxylate (II) Compound (II) when reacted with hydrazine hydrate in ethanol yielded pyridine- 3- carboxylic acid hydrazine (III) and on treatment with aromatic acids in the presence of phosphorus oxychloride affords 3- (5- substituted phenyl-1, 3, 4- Oxadiazol- 2- yl) pyridines (IVa-e). The overall reaction of Scheme given below;

Oxone, Potassium peroxomonosulfate - Organic …

Synthesis of ethyl pyridine- 3- carboxylate (II): A mixture of pure nicotinic acid (I) (0.5mol), 100ml of ethanol and 50ml of Conc. Sulphuric acid were refluxed for 4hrs on a steam bath. After cooling the solution, it was poured in to crushed ice and neutralized by strong ammonia solution, ester separates as oil. Extract the solution with anhydrous magnesium sulphate. Ether was removed by evaporation on a water bath and the residue of ethyl pyridine-3-carboxylate was obtained.

Oxone, Potassium peroxomonosulfate

Synthesis of Pyridine- 3- Carboxylic acid Hydrazine (III): A mixture of ethyl pyridine-3-carboxylate (II) and hydrazine hydrate in equimolar portion and 15ml of ethanol was refluxed for 4-6hrs. On cooling crude product was separated out. It was filtered, collected and recrystallized from ethanol.

The composition of the oxidizing agent Oxone® is 2KHSO 5

General Procedure for Synthesis of 3 (5- aryl- 1, 3, 4- oxadiazole- 2- yl) - pyridine derivatives (IVa-e): A mixture of nicotinic acid hydrazine (III) (0.01mol) and various aromatic acids (0.01mol) in phosphorus oxychloride (5-10ml) was refluxed for 5-6hrs. The contents were cooled and poured into crushed ice. It was neutralized with sodium bicarbonate solution and resulting solid was filtered, dried and recrystallized from suitable solvent to obtained corresponding derivatives.