acylated Evans’ chiral auxiliary and an aldehyde ..

In an early example of the use of a chiral auxiliary in asymmetric synthesis, ..

The stereochemistry of the chiral auxiliary…

AB - The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).

The first example of such an immobilized Evans auxiliary was published by Allin and Shuttleworth and applied in the synthesis of an

Chiral Auxiliaries in Asymmetric Synthesis - …

From that time on, several immobilized auxiliaries, especially Evans oxazolidinones and proline-type auxiliaries, were developed and applied to different reactions.

The employment of chiral auxiliaries in industrial drug discovery processes is limited, due to their price and availability.

and , 2003. New routes to chiral Evans auxiliaries by enzymatic desymmetrisation and resolution strategies. Advanced Synthesis & Catalysis, 345 (6-7), pp. 835-848.


used chiral auxiliaries, oxazolidinones (Evans ..

Especially the use of polymer-bound chiral auxiliaries have not been studied extensively, although a chiral auxiliary on solid support offers some reasonable advantages over auxiliaries in solution phase.

Chiral auxiliaries - WikiVisually

, , , and , 2013. Solid-phase asymmetric synthesis using a polymer-supported chiral Evans'-type oxazolidin-2-one. Nature Protocols, 8 (10), pp. 1890-1906.

The 4-benzyl-2-oxazolidinone chiral auxiliary developed by Evans ..

N2 - The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).

using different resin-bound aldimines 1 and a chiral auxiliary at C-3

Especially the use of polymer-bound chiral auxiliaries have not been studied extensively, although a chiral auxiliary on solid support offers some reasonable advantages over auxiliaries in solution phase.

bromobutyric acid using N-phenyl pantolactam as a chiral auxiliary ..

N2 - Asymmetric synthesis of all four isomers of β-methyl-2′,6′-dimethylphenylalanine was accomplished with complete stereoselectivities and high yields by using the Evans-like auxiliary 4-phenyl-oxazolidinone as a chiral auxiliary and as a chiral resolution reagent.

is now known as a Schöllkopf chiral auxiliary

AB - Asymmetric synthesis of all four isomers of β-methyl-2′,6′-dimethylphenylalanine was accomplished with complete stereoselectivities and high yields by using the Evans-like auxiliary 4-phenyl-oxazolidinone as a chiral auxiliary and as a chiral resolution reagent.

• Chiral Auxiliary assists the substrate to react in a ..

Chiral auxiliaries were introduced by in 1978 withchiral andby B.M. Trost in 1980 with chiral . The menthol compound isdifficult to prepare and an alternative is introduced byJ. K. Whitesell in 1985.