Research Educator: Elizabeth Ilardi
Our main motivation to edit was to update the major advancements in this field through several chapters written by renowned experts who have largely contributed to the recent progresses. Illustrated with more than 200 colour figures and including literature citations mostly from the last decade, this book covers the recent chemical methods of glycoconjugates and clearly highlights their diverse biological properties. analyzes the structure of lectins from pathogenic bacteria and gives structure/function relationships that are crucial for the development of high affinity ligands. In carbohydrate binding by FimH is discussed and modern means for its investigation including photoaffinity labelling are described. Very recent crystallographic work is also documented that provides an explanation for shear-enhanced binding of type 1 fimbriated E. coli. summarizes the most convenient methodologies for the synthesis of glycocalixarenes and describes their impressive aggregation properties and many other biological applications. illustrates examples of bacterial and human lectins together with bacterial toxins having varied number of carbohydrate recognition domains that necessitated multivalent glycoconjugates. It focuses on glycofullerenes that have been used to describe novel synthetic strategies and possible fit with concomitant lectins. In the structures of the cholera and E. coli heat-labile toxins are described. The authors also summarize the main strategies that have led to the development of monovalent and multivalent inhibitors of these toxins and they discuss the importance of chelation and protein aggregation as mechanisms of multivalent inhibition. focuses on the design of high affinity ligands for galectins and provides a better knowledge of the implications of these proteins in biology. demonstrates that combinatorial chemistry led to the discovery of glycopeptide dendrimers as strong ligands for lectins or drug-delivery systems and shows how the amino acid composition of the dendrimer branches can influence their biological activity. focuses on the synthesis of a recent class of glycoclusters displayed on a cyclopeptide platform and highlights their promising biological properties, in particular as inhibitors or synthetic vaccines. shows that the cellular delivery and bioavailability of oligonucleotides can be improved by their conjugation with carbohydrates and also describes the construction of carbohydrate biochips or glycoclusters using these conjugates. focuses on glycoliposomes and covalently-functionalized glyconanoparticles which make use of the “glyco-code” to address specifically pathogens or pathological-related problems. focuses on the synthesis of glycoproteins, glycopeptides, glycosylated natural compounds, carbohydrate-functionalized surfaces and nanoparticles using chemoselective glycosylation. In the recent developments in glycosidase-catalyzed synthesis of unnatural semi-synthetic carbohydrate structures are presented. reports the synthesis of glycomimetics and glycopeptidomimetics using hetero-Diels Alder reactions between α,α'-dioxothiones and glycals. aims at describing the usual methods to characterize protein-carbohydrate interactions, namely inhibition of hemagglutination assay, enzyme-linked lectin assays, isothermal titration calorimetry, surface plasmon resonance and the more recent atomic force microscopy.
Principal Investigator: Stephen Martin
Biological Signal Acquisition and Analysis
MacLeod and Boynton Color Space OCX
, , and form a leading centre for research in photosynthesis and bioenergetics in plants and cyanobacteria. Their work interfaces with that of structural biologists and protein chemists in Chemistry and Biochemistry and plant scientists and environmental microbiologists in Organismal Biology. The team have gained international recognition for their innovative work on the dynamic properties of photosynthetic membranes and the regulation of photosynthetic light harvesting and electron transport.