Inhibition of prostaglandin synthetase by Su‐21524 (Abstract).

Metabolism of prostaglandin E1 in guinea pig lung: the structures of two metabolites.

Synthesis and biological properties of 16‐alkylprostaglandins.

To form a basis for further investigations in this area, the present study has isolated and identified the metabolites formed from exogenous arachidonic acid by adrenal zona glomerulosa cells and characterized the effects of several inhibitors on the synthesis of these eicosanoids.

Dependence of pulmonary prostaglandin metabolism on carrier‐mediated transport processes.

Stimulation of prostaglandin biosynthesis by adenine nucleotides.

Metabolism and covalent binding of [3H]benzo(a)pyrene by isolated perfused lungs and short‐term tracheal organ culture of cigarette smoke‐exposed rats.

Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesis.

Human Diseases6.1 Cancers: Overview6.2 Cancers: Specific types6.3 Immune diseases6.4 Neurodegenerative diseases6.5 Substance dependence6.6 Cardiovascular diseases6.7 Endocrine and metabolic diseases6.8 Infectious diseases: Bacterial6.9 Infectious diseases: Viral6.10 Infectious diseases: Parasitic6.11 Drug resistance: Antimicrobial6.12 Drug resistance: Antineoplastic

Metabolism of [2‐14C]prostaglandin E1 on passage through the pulmonary circulation.


Synthesis and metabolism of prostaglandins, …

So how much of these oils do you need to promote the healthy balance that I spoke about above? First of all, you have to keep in mind that there exists a balance between LA and LNA. Too much of one can interfere with the eicosanoid pathways of the other, or even the proper metabolism of itself. Some researchers, including Dr. Udo Erasmus, have reasoned that because bodily enzymes convert w6s only about one-fourth as efficiently as they do w3s, we should take a 4:1 ratio of LA to LNA. Others, however, prefer a lower ratio of LA to LNA, even as low as 1:1. Perhaps a better approach is to determine the amount of each type of oil that is necessary for maximum health and let the exact ratios take care of themselves.

Synthesis of prostaglandins and leukotrienes



A graphical chart of the metabolism of the eicosanoids may be found on the web site.

Isoprostanes and analogues

Between 1975 and 1981, the formation of prostaglandin-like molecules was several times reported to be the result of peroxidation in vitro of arachidonic acid and by a free radical mechanism independent of the cyclooxygenase.

Metabolism of prostaglandins in the kidney - …

The identification of these new metabolites opens the way for the study of how phospholipid-bound prostaglandins may play a role during platelet function.
PGE2 has been isolated from Japanese red alga as a result of studies aimed at determining the cause of a human intoxication syndrome named "Ogonori poisoning" ().

Synthesis and metabolism of prostaglandins E2, F2α …

However, it isn't quite as clear-cut as simply labeling the series 2s as "bad". Some series 2 eicosanoids actually counter the "bad" effects of the others series 2s, and so compensate, at least partially, for what would be considered "negative" effects. For instance, prostacyclin PGI2 counters some of the negative effects of prostaglandin PGE2 by inhibiting platelet aggregation and activating leukocytes (which is good). In addition, a couple of the series 2s are potent stimulators of muscle growth. When muscle cells are strenuously trained they release the series 2 prostaglandins PGE2 and PGF2-alpha. PGE2 increases protein degradation, but it also potently induces muscle satellite cell proliferation and infusion, leading to muscle growth. PGF2-alpha increases protein synthesis, suspectedly by increasing protein synthesis "efficiency" at the ribosomes. It also seems to destroy fat cells. (Is that possible support for the theory of "spot reduction" that the old-timers swore by? Train a muscle more often, release more PGF2-alpha, destroy more fat cells?! Incidently, recent research has given scientific support to the concept of "spot reduction".)

taking aspirin reduces synthesis of prostaglandins, ..

Interludes between births are also a good time to provide some general supportivemeasures to the bitch. Though it is not recommended for the bitch to ingest substantialquantities of food and water prior to the successful completion of delivery of the entirelitter, small amounts of water or ice cubes will help to prevent dehydration, especiallyduring long deliveries. Additionally, labor is very taxing on the bitches' energymetabolism and sugar storage, therefore, providing a source of sugar in the form of smallamounts of Karo syrup or Nutri-cal will help to replace depleted energy sources.