Chemoenzymatic Synthesis of Glycoconjugates and Biological ..

Chemoenzymatic synthesis of glycoconjugates and biological applications.

Synthesis and Biological Applications of Glycoconjugates, ..

This thesis describes the development and synthesis of multicalixarenes and their
application in gene and drug delivery.
Chapter 1 provides an introduction to gene therapy and calixarenes. The synthesis of two
families of amino functionalised multicalixarenes are described. Evaluation of their toxicity
and transfection studies are reported and a number of candidates for development identified.
Chapter 2 describes the development of calixarene glycoconjugates using a wide range of
approaches. The synthesis of calixarene glycoconjugates through click chemistry is
reported and the development of the first multicalixarene glycoconjugate is discussed.
Chapter 3 reviews the development of large multicalixarenes assemblies. The synthesis of
large (9 and 21 member) click based multicalixarenes is described.

12/12/2017 · Synthesis and Biological Applications of Glycoconjugates

Glycoconjugates are biologically important ..

This thesis describes the development and synthesis of multicalixarenes and their
application in gene and drug delivery.
Chapter 1 provides an introduction to gene therapy and calixarenes. The synthesis of two
families of amino functionalised multicalixarenes are described. Evaluation of their toxicity
and transfection studies are reported and a number of candidates for development identified.
Chapter 2 describes the development of calixarene glycoconjugates using a wide range of
approaches. The synthesis of calixarene glycoconjugates through click chemistry is
reported and the development of the first multicalixarene glycoconjugate is discussed.
Chapter 3 reviews the development of large multicalixarenes assemblies. The synthesis of
large (9 and 21 member) click based multicalixarenes is described.

25/04/2017 · Glycoconjugates : Solid-phase synthesis and biological applications

Dr. Manoj B. Gawande received his Ph.D. degree in Chemistry in 2008 from Institute of Chemical Technology, Mumbai, India. After several research stays in Germany, South Korea, Portugal, and England, he recently worked as a Visiting Professor at CBC-SPMS, Nanyang Technological University, Singapore. Presently, he is senior researcher at RCPTM, Palacky University, Olomouc, Czech Republic. His research interests are nanocatalysis, design of nanocatalysts, and their applications in greener organic synthesis; he has published over 50 scientific papers.

Synthesis and Biological Applications of Glycoconjugates, Bentham e-Books (2011), pp


Understanding the role that carbohydrates play in many biological ..

Juan Xie was born in China in 1964. After graduating from China Pharmaceutical University, she studied chemistry at University Paul Sabatier (Toulouse III) in France and obtained a “DEA” in 1985 and a Ph.D. at University Paris V in 1998 under the supervision of Professors M. C. Fournier-Zaluski and B. P. Roques. After postdoctoral study at CNRS in the group of Dr. M. Wakselman, she moved to University Paris VI as an Assistant Professor (1991). In 2004, she moved to the Department of Chemistry of Ecole Normale Supérieure de Cachan as a full Professor. Her current research is focused on the design, synthesis, and study of bio- or photoactive molecules, including stereocontrolled synthesis of carbohydrate derivatives and glycoconjugates for biological applications, synthesis of fluorescent amino acids/carbohydrates, or carbohydrate-based fluorescent macrocycles as molecular receptors for molecular and ionic recognition.

rapid synthesis of glycoconjugates: ..

(2013) Synthesis of Novel Calix[4]arene Based Dendrimers and their Biological Applications. Doctoral thesis, University of East Anglia.

Progress and recent achievements in the synthesis of glycoconjugates

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