1,2-Amino Alcohols and Their Heterocyclic Derivatives …

Antibacterial and antifungal activity of imidazo[1,5-a]quinoxaline derivatives 4 ..

PDF Downloads : Oriental Journal of Chemistry

Chem., 11, 2149-2156.

Jaso, A., Zarranz, B., Aldana, I., and Monge, A.(2005) Synthesis of New Quinoxaline-2-carboxylate 1,4-Dioxide Derivatives as Anti-Mycobacterium tuberculosis Agents, J.

BACHELOR OF PHARMACY (HONS) - AIMST University

(2007) Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues, Bioorg.

In continuation of our study, we report the synthesis of novel Schiff’s bases incorporating quinoxaline moiety. Quinoxalines constitutes an important class of compounds, some analogs are synthesized and evaluated for antimicrobial activity (; ) and many possess diverse biological activity such as insecticides, fungicides, herbicides, anthelmintics and antiviral (; ). Among the various classes of nitrogen heterocyclic compounds, quinoxaline derivatives display a broad spectrum of biological activities. This has contributed to their usefulness in combinatorial drug discovery libraries (). Synthetic quinoxaline ring is the part of a number of antibiotics which are known to inhibit the growth of gram positive bacteria and are also active against In addition, Schiff’s bases are also known for their antibacterial and antitubercular activity (; ; ). In the present study, we describe the synthesis of novel Schiff’s bases incorporating quinoxaline moiety. Title compounds were screened for their antibacterial, antifungal and antimycobacterial activity by broth dilution method. In the study of its biological activity against selected strains of bacteria and fungi, it has been investigated for their Minimum Inhibitory Concentration (MIC).


synthesis of imidazo[1,5-a]quinoxaline ..

Despite the fact that these compounds and their derivatives have potent donor groups, the studies directed towards exploring the ligational behaviour of them are limited. Hence, we report, herein, the synthesis and characterization of VO(IV), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Zn(II), and Pd(II) complexes with 2-furaldehyde-2-(3-chloro-2-quinoxalinyl) hydrazone [FCCQH] (Fig.1), followed by their screening for antimicrobial and anticancer activities.

Antibacterial and antifungal activity.

Among the various classes of nitrogen containing heterocyclic compounds, benzimidazoles and quinoxalines have been shown 12 to exhibit a wide range of biological and pharmacological properties. The benzimidazole derivatives have commercial application in veterinary medicine as anthelmintic agents 13 and in such diverse human therapeutic areas 14-17 as anti-ulcerous, anti-hypertensive, anti- viral, anti-fungal, anti-cancerous and antihistaminic agents. In view of the importance of the quinoxolines, we undertook the synthesis of these title compounds.

Synthesis and antibacterial activity of 1-hydroxy-1 …

2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C2 chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde (4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a–e, 4-(2-methyl-quinoxaline-3-yloxy)benzamine (6) and 4-(2-methylquinoxalin-3-yloxy)-N-substituted benzylidine benzamines 7a–e were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.

, and of several of its derivatives are reported

In the view of the present study, we have efficiently synthesized N-arylquinoxalin-2-amines containing some new type of benzimidazole derivatives and which were screened for their antibacterial activity. Our Efforts was mainly focused on the synthesis and development of some new type of 3-Chloro-N-((5 - chloro - 1 - tosyl - 1 H - benzo [d] imidazol - 2 -yl)methyl)-N-arylquinoxalin-2-amines (5a-e) from compound (4) by using 4-chloro-N-1-tosylbenzene-1, 2-diamine by adopting simple procedure. Among the synthesized compounds 5c, 4c, 5b, 4b were exhibit significant antibacterial activity against standard drug. And all synthesized compounds were characterized by elemental analysis, 1HNMR, 13CNMR and Mass spectral data.