Siderophore synthesis essay - Aishlo
Biological tests indicated that the synthetic mycobactin S was a potent growth inhibitor of H37Rv, though it differs in only one stereogenic center from mycobactin T, the siderophore growth promoter of
Role of Siderophore Biosynthesis in Virulence of ..
Siderophores have applications in medicine for iron and aluminum overload therapy and antibiotics for better targeting. Understanding the mechanistic pathways of siderophores has led to opportunities for designing small-molecule inhibitors that block siderophore biosynthesis and therefore bacterial growth and virulence in iron-limiting environments.
(grasses) including agriculturally important species such as and are able to efficiently sequester iron by releasing phytosiderophores via their into the surrounding . Chemical compounds produced by microorganisms in the rhizosphere can also increase the availability and uptake of iron. Plants such as oats are able to assimilate iron via these microbial siderophores. It has been demonstrated that plants are able to use the hydroxamate-type siderophores ferrichrome, rodotorulic acid and ferrioxamine B; the catechol-type siderophores, agrobactin; and the mixed ligand catechol-hydroxamate-hydroxy acid siderophores biosynthesized by saprophytic root-colonizing bacteria. All of these compounds are produced by rhizospheric bacterial strains, which have simple nutritional requirements, and are found in nature in soils, foliage, fresh water, sediments, and seawater.
Variation in Siderophore Biosynthetic Gene Distribution and ..
Siderophores are avid iron chelating agents synthesized by numerous microorganisms to sequester iron in environments where it is typically available in an insoluble form (). Considerable attention has been devoted to the nutritional importance, genetic regulation, virulence factor and uptake function of these molecules ().
Siderophore synthesis essay - The Exorcism of Danny …
Elizabeth M. Nolan was born in Albany, New York, and graduated magna cum laude from Smith College in 2000 with highest honors in chemistry. As an undergraduate, she conducted computational research with Professor R. G. Linck, which addressed long-range stereoelectronic effects in substituted alkanes. She was named Beckman Scholar, elected into Phi Beta Kappa, and received a Fulbright Scholarship. She conducted her graduate studies in inorganic chemistry at the Massachusetts Institute of Technology, where she joined the laboratory of Professor Stephen J. Lippard. Her doctoral research focused on the synthesis, characterization, and application of small-molecule fluorescent sensors for detecting zinc in biological samples and mercury in aqueous solution. She was a recipient of a NDSEG graduate fellowship and a National Young Investigator Award from the ACS Division of Inorganic Chemistry. Liz is currently a NIH postdoctoral fellow in the laboratory of Professor Christopher T. Walsh at Harvard Medical School. She is studying several proteins involved in the assembly of an antibiotic “Trojan horse” peptide that targets Gram-negative bacteria expressing siderophore uptake pumps.