The invention discloses a synthesis method of resorcinol

Resorcinol for Synthesis - CDH Fine Chemical

RESORCINOL FOR SYNTHESIS - Chemistry

Current resorcinol manufacture (Scheme 1) employs benzene as a starting material. Benzene is carcinogenic and volatile and is obtained from nonrenewable petroleum feedstocks. All of resorcinol's carbon atoms in the proposed syntheses would be derived from the carbon atoms of glucose. In addition to being nontoxic and nonvolatile, glucose can be derived from the renewable starch and cellulose content of plants cultivated on an enormous scale in the United States. Resorcinol's oxygen atoms also would be derived from the oxygen atoms of glucose. Use of a starting material that already contains what will become the two oxygen atoms of resorcinol avoids high-temperature fusion with caustic lye, high-salt effluent streams, and explosive intermediates that are associated with chemically forcing oxygen atoms onto the aromatic ring of benzene.

The primary objective of the proposed research is to establish the basic route(s) by which resorcinol can be synthesized from glucose.

Synthesis of resorcinol from meta-phenylenediamine in …

Resorcinol is a white crystalline solid that turns pink upon exposure to light if not completely pure. The substance is flammable, although ignition is difficult. It is slightly toxic and is used to make plastics and as a chemical intermediate for the synthesis of pharmaceuticals and other organic compounds. It is used in the production of diazo dyes and plasticizers and as a UV absorber in resins.

The primary objective of the proposed research is to establish the basic route(s) by which resorcinol can be synthesized from glucose.

Current resorcinol manufacture (Scheme 1) employs benzene as a starting material. Benzene is carcinogenic and volatile and is obtained from nonrenewable petroleum feedstocks. All of resorcinol's carbon atoms in the proposed syntheses would be derived from the carbon atoms of glucose. In addition to being nontoxic and nonvolatile, glucose can be derived from the renewable starch and cellulose content of plants cultivated on an enormous scale in the United States. Resorcinol's oxygen atoms also would be derived from the oxygen atoms of glucose. Use of a starting material that already contains what will become the two oxygen atoms of resorcinol avoids high-temperature fusion with caustic lye, high-salt effluent streams, and explosive intermediates that are associated with chemically forcing oxygen atoms onto the aromatic ring of benzene.


Synthesis of Methylene diresorcinol: You cannot overwrite this file

Having established conditions for high-yielding conversion of TAL into resorcinol, attention was next focused on creation of an organism capable of biosynthesizing TAL from glucose. One approach for TAL biosynthesis was to utilize 6-methylsalicylic acid synthase (MSAS), an enzyme found in a number of organisms, including Penicillium (P.) patulum. MSAS is a multifunctional enzyme that catalyzes at least 11 separate reactions (Scheme 3) that result in conversion of acetyl-CoA and two molecules of malonyl-CoA into 6-methylsalicylic acid. These reactions are carried out by catalytic active sites possessing ketosynthase, ketoreductase, and dehydrase functions. It already had been established that TAL is a byproduct formed by MSAS, even in the presence of NADPH concentrations that are optimal for formation of 6-methylsalicylic acid. In the absence of NADPH, TAL is the exclusive product synthesized by MSAS. Altering MSAS by inactivation of the ketoreductase site was expected to result in formation of TAL.

resorcinol, 108-46-3 - The Good Scents Company

Resorcinol is a white crystalline solid that turns pink upon exposure to light if not completely pure. The substance is flammable, although ignition is difficult. It is slightly toxic and is used to make plastics and as a chemical intermediate for the synthesis of pharmaceuticals and other organic compounds. It is used in the production of diazo dyes and plasticizers and as a UV absorber in resins.

PDF Downloads : Oriental Journal of Chemistry

, , , , and (2003) The desymmetrisation of resorcinol: The synthesis of resorcinol monoalkyl ethers. Synlett (7). pp. 997-1001. ISSN 0936-5214

Journal of Nanoscience and Nanotechnology

Having established conditions for high-yielding conversion of TAL into resorcinol, attention was next focused on creation of an organism capable of biosynthesizing TAL from glucose. One approach for TAL biosynthesis was to utilize 6-methylsalicylic acid synthase (MSAS), an enzyme found in a number of organisms, including Penicillium (P.) patulum. MSAS is a multifunctional enzyme that catalyzes at least 11 separate reactions (Scheme 3) that result in conversion of acetyl-CoA and two molecules of malonyl-CoA into 6-methylsalicylic acid. These reactions are carried out by catalytic active sites possessing ketosynthase, ketoreductase, and dehydrase functions. It already had been established that TAL is a byproduct formed by MSAS, even in the presence of NADPH concentrations that are optimal for formation of 6-methylsalicylic acid. In the absence of NADPH, TAL is the exclusive product synthesized by MSAS. Altering MSAS by inactivation of the ketoreductase site was expected to result in formation of TAL.