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Presentation Summary : Cholesterol Absorption, Synthesis, & Metabolism I ... glucocorticoids & low ATP levels inactivate HMG-CoA ... & Metabolism I Author: elizabeth medina Last modified by:
Cholesterol biosynthesis - [PPT Powerpoint]
Lipid biosynthesis, biosynthetic pathway for tri-acylglycerols, phosphoglycerides, sphingomyelin and prostaglandins. metabolism of cholesterol and its regulation.
Cholesterol is constituent of all cell membrane. necessary for synthesis of steroid hormones, bile salts and vitamin d. carried as ester & free cholesterol in the
Regulation of Blood Cholesterol Levels.
80% of endogenous cholesterol is formed in the liver. Enzymes involved in the synthesis are partly located in the endoplasmic reticulum and partly in the cytoplasm. Acetyl CoA is the precursor. HMG CoA, mevalonate, isopentenyl pyrophosphate, squalene are some of the important intermediate compounds formed during cholesterol synthesis. Cholesterol is transported in lipoprotein complexes. Elevation of lipids in blood leads to the deposition of cholesterol on the arterial walls leading to atherosclerosis.