Synthesis of Aspirin Lab Report Essay Examples
An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. It is the two-step synthesis of aspirin starting from oil of wintergreen. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer. To understand the chemistry, the student must be able to recognize the common molecular framework shared by oil of wintergreen, salicylic acid, and aspirin and to identify the -OH and -CO2 sites where chemical changes occur. The experiment differs in three ways from traditional aspirin synthesis experiments for general chemistry. It is designed to be performed early rather than late; it starts from a naturally occurring material and requires two steps rather than one; and it utilizes FTIR spectroscopy to distinguish among oil of wintergreen starting material, salicylic acid intermediate, and aspirin product. The use of FTIR spectroscopy introduces students to a modern analytical technique that is currently used in research involving aspirin.
Synthesis and Characterization of Aspirin - Odinity
The saga of COX inhibitors continues. Already the second generation of COX2 inhibitors is in the development pipeline. As long as people need pain killers without side effects, research continues.
Both Celebrex and Vioxx made the 2001 list of top ten drugs by global sales, beating the famous impotence drug Viagra, introduced in 1998. Clinical superiority is not the only reason for the high dollar sales of COX2 inhibitors. Another reason is that super aspirins are much more expensive than aspirin. Social critics grumble that the new drugs are not worth their high prices, but people whose drug bills are covered by health insurance do not care. They demand the best, whether or not aspirin upsets their stomachs; they pay the same insurance premium anyway. COX2 inhibitors grossed $5.7 billions and accounted for 23 percent of the pain and inflammation drug market in 2001. That was smaller than the 30 percent for the old COX inhibitors, but the trend of replacement was unmistakable. Optimistic analysts projected that by 2010, the market share of COX2 inhibitors would more than double that of COX inhibitors.
Synthesis of Aspirin and Oil of Wintergreen - …
Becauseaspirin is not very soluble in water, it can be isolated by addition of cold water to thereaction mixture followed by a gravity filtration.
Synthesis of Aspirin and Oil of Wintergreen ..
Enzymes are protein catalysts that speed up chemical reactions without being themselves used up in the reactions. An enzyme is a huge molecule with an active area that works somehow like a mold that accepts certain raw pieces and casts them into a final form. Imagine a mold that stamps a rod and a bowl into a spoon. Spoon production would be disrupted if someone throws a monkey range into the mold. Such a monkey range – an enzyme inhibitor – would make a desirable drug if it stops an enzyme from producing disease-inducing chemicals. Aspirin is an enzyme inhibitor. It suppresses the action of the enzyme COX, stops the production of prostaglandin, thus disrupting the pathways to pain, inflammation, elevated temperature, and stomach protection.
Synthesis of Aspirin | Sharmaine Bungabong - …
The quantity in the denominator (2.5 g) represents the theoretical yield of aspirin based on the moles of salicylic acid and acetic anhydride used in the synthesis.
For the synthesis of aspirin from ..
How does aspirin curb prostaglandin production? The many kinds of prostaglandin are synthesized by a host of complicated biochemical pathways. However, all pathways share a common stage facilitated by an enzyme called COX, whose action aspirin suppresses.
The synthesis reaction of aspirin is ..
Over the years, researchers have assembled a large library of how a kind of tissue reacts physically and chemically to various kinds of irritants. For instance, a tissue secrets a specific substance when it is exposed to a chemical known to cause inflammation in people, and that substance in turn causes another tissue to twitch. A bioassay test exposes a piece of partially known tissue to a novel environment and records the tissue’s reaction to figure out unknown characteristics of it or the environment. Vane had developed a powerful bioassay technique in which a sequence of tissues probed a chain of chemical reactions. When Collier approached him, he agreed to investigate what happened when he exposed tissues to pain-inducing chemicals, and what happened if he added aspirin to the chemicals.