Biosynthesis of Lipids | Cholesterol | Biosynthesis
Table 2 shows the effects of overexpression of various SREBP genes on cholesterol and fatty acid synthesis, and on liver cholesterol and triglyceride content; note that a value of 1 represents wild-type levels, while a value above 1 represents higher-than-wild-type levels
the first fatty acids ester which is a rate-limiting step
Table1 shows that cholesterol and fatty acid synthetic activity, as well as livertriglyceride content, declined from wild-type levels in all transgenic micethat survived into adulthood. Liver cholesterol content increased in SREBP-1cknockouts, declined in SCAP inactivated mice and SREBP-1a/1c double knockouts, and was unchanged in S1P-inactivated mice.
The expression of genes that encode proteins involved in the synthesis of cholesterol (HMG-CoA reductase) and uptake of cholesterol (LDL receptor) is regulated by the sterol response element binding protein (SREBP).