GI: Fatty acid biosynthesis Flashcards | Quizlet
Chajes V, Cambot M, Moreau K, Lenoir GMand Joulin V: Acetyl-CoA carboxylase alpha is essential to breastcancer cell survival. Cancer Res. 66:5287–5294. 2006. : :
Fatty Acid Synthesis and Pyruvate Metabolism …
Menendez JA and Lupu R: Mediterraneandietary traditions for the molecular treatment of human cancer:anti-oncogenic actions of the main olive oil’s monounsaturatedfatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol. 7:495–502.2006.
The neonatal onset type B pyruvate carboxylase deficiency has a greater incidence in France, although it has been described in Canada, Egypt, and Saudi Arabia.
Fatty acid Biosynthesis- Subjective Questions- Set-1
In a study by Monnot et al, the authors concluded that their results, along with data already culled from previously identified PC mutations, indicated that type A PC deficiency is caused by the association of 2 missense mutations found in either the biotin carboxylase or carboxyltransferase (N-terminal part) domain of the PC molecule, while type B consistently arises from at least 1 truncating mutation, which in most cases occurs in PC's carboxyltransferase (C-terminal part) or biotin carboxyl carrier protein domain. The investigators examined 9 novel mutations of the PC gene in 5 unrelated patients, 2 of whom had type A and 3 of whom had type B PC deficiency.[4, 5]
Acetyl-CoA carboxylase (in cytosol)
Hypoglycemia may occur during fasting because of reduced gluconeogenesis. The period of fasting required to produce symptoms is much shorter in pyruvate carboxylase (PC) deficiency than in other disorders.
Fatty Acid Synthesis: Activation, Steps and Control
Type B pyruvate carboxylase (PC) deficiency is associated with ventricular dilation, cerebrocortical and white matter atrophy, or periventricular white matter cysts.
Fatty acid synthesis occurs similarly to Beta-oxidation ..
Chapter 36, Objective 18: Explain how increased fatty acid oxidation and decreased insulin spares blood glucose by muscle in the fasting and resting state.
Acetyl-CoA carboxylase (ACC) ..
The gene that encodes pyruvate carboxylase (PC) has been localized to chromosome band 11q13.4-q13.5. PC deficiency is inherited from parents by an autosomal recessive inheritance pattern. Neonatal PC deficiency is associated with a complete absence of PC messenger ribonucleic acid (mRNA) and the PC enzyme protein. Infantile-onset PC deficiency is associated with residual enzyme activity that is less than 2% of normal.