Synthesis of 5-substituted pyrrole-2-carboxaldehydes

Organotin Complexes With Pyrrole-2 ELSEVIER carboxaldehyde Monoacylhydrazones
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1H-Pyrrole-2-carboxaldehyde, 3,5-dimethyl-(CAS# 2199 …

Synthesis of Schiff base ligand L1 (Pyrrole-2-carboxaldehyde thiosemicarbazone): Hot ethonolic solution (50 ml) of thiosemicarbazide (4.55 gm, 0.05 mol) and pyrrole-2-carboxaldehyde (4.75 gm, 0.05 mol) mixed slowly with constant stirring in presence of acetic acid. This mixture was refluxed for 2 hours on a water bath. On cooling a cream colored compound was precipitated out. It was filtered washed with cold ethyl alcohol and dried under vacuum over P4O10. This reaction is a type of condensation reaction which takes place between aldehyde/ketone and thiosemicarbazide with elimination of water molecules which form thiosemicarbazones. The reaction can be represented as below.

Pyrrole-2-carboxaldehyde and salicyl hydrazide in water undergocondensation reaction to produce PCSH in good yield (88%).
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1H-Pyrrole-2-carboxaldehyde, 3,5-dimethyl- supply

Thiophene-2-carboxaldehyde is used in the preparation of beta-aryl-beta-amino acids and urea derivatives. It acts as an arylation reagent. Further, it is used in the synthesis of unsaturated ketones, which serve as antiviral and cytotoxic agents. In addition to this, it is used as an intermediate to manufacture pharmaceuticals and aromatic compounds.

CAS No.1192-58-1,1H-Pyrrole-2-carboxaldehyde,1 …
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ABSTRACT: Ni(II) and Cu(II) complexes of Schiff base thiosemicarbazones (L1) and semicarbazones (L2) derived from pyrrole-2-carboxaldehyde. These complexes are characterized by elemental analysis, molar conductance measurements, magnetic suscepectibility measurements, mass, IR, electronic and EPR spectral studies. The molar conductance measurements of the complexes in DMSO determine the non-electrolytes and electrolytes nature of the complexes based on their molar conductance value as higher value indicates the electrolytes nature of the complexes and lower value of the molar conductance indicates the non-electrolytes nature of the complexes. On the basis of spectral studies an octahedral geometry may be assigned for Ni(II) complexes except [Ni(L1)2](NO3)2 which are of tetrahedral geometry. A tetragonal geometry may be suggested for Cu(II) complexes.

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PYRROLE-2-CARBOXALDEHYDE, CAS Number: …

In present paper, we report the synthesis and characterization of Ni(II) & Cu(II) complexes with thiosemicarbazones (L1) and semicarbazones (L2) derived from pyrrole-2-carboxaldehyde.