Synthesis of Densely Substituted Pyrimidine Derivatives

T1 - Synthesis of novel indolyl-pyrimidine antiinflammatory, antioxidant and antibacterial agents

Synthesis of Densely Substituted Pyrimidine Derivatives Omar K

Falcao EPS, de Melo SJ, Srivastava RM, Catanho MTJA. Do Nascimento SC. Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines. Eur J Med Chem 2006;41:276-82.

A REVIEW ON THE SYNTHESIS AND THERAPEUTIC POTENTIAL OF PYRIMIDINE DERIVATIVES

Single-Step Synthesis of Pyrimidine Derivatives

The formamide active methylene synthesis is illustrated by the condensation of acetophenone with two molecules of formamide in presence of zinc chloride at high temperature to give pyrimidine intermediate.7

The synthesis may be used more effectively by combining the molecules of formamide as trisformamidomethane, which may then furnish N- formyl formamidine, thus acetone and this reagent with toluene sulphonic acid as catalyses yield 4-methyl pyrimidines.7


SYNTHESIS OF PYRIMIDINE AND PYRIMIDINTHIONE

Preparation of Pyrimidines: Synthetic strategies’ of Pyrimidines have involved four main routes based on the condensation of two fragments as illustrated by VI-IX;

A convenient synthesis of a pyrimidine based bis-tridentate metal ..

Gholap AR, Toti KS, Shirazi F, Deshpande MV, Srinivasan KV. Efficient synthesis of antifungal pyrimidines via palladium catalyzed Suzuki/Sonogashira cross-coupling reaction from Biginelli 3, 4-dihydropyrimidin-2 (1 H)-ones. Tetrahedron 2008;64:10214-23.

Prebiotic synthesis of diaminopyrimidine and thiocytosine

Hockova D, Holy A, Masojidkova M, Andrei G, Snoeck R, Clercq ED. Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. Balzarini J Bioorg Med Chem 2004;12:3197-202.

Anti-parasitic guanidine and pyrimidine alkaloids from …

The application ofthe proposed method to the synthesis of other hydrogenated 2-iminopyrimidines,including heterocyclic guanidine natural alkaloids and their analogs, iscurrently in progress.

Anti-parasitic guanidine and pyrimidine alkaloids from the marine ..

The 4- oxopyrazolo [3, 4- d] pyrimidines- 6- thione synthesized from 1, 3- diaryl- 5-ethoxy methylene- 2- thiobarbituric acid in the presence of hydrazine hydrate in ethanol/acetic acid for 8 hours.18

SYNTHESIS OF SOME PYRIDINE, PYRIMIDINE AND …

Rostom SAF, Badr MH, Abd El Razik HA, Ashour HMA, Abdel Wahab AE. Synthesis of Some Pyrazolines and Pyrimidines Derived from Polymethoxy Chalcones as Anticancer and Antimicrobial Agents. Arch Pharm Chem Life Sci 2011;344:572-87.