We asked: (1) Is resection amount related to prosthetic infection

Infection of the hip prosthesis may require removal of the prosthesis and antibiotic treatment.

{Peri-prosthetic infection PJI} - Osteomyelitis

3. Kunutsor SK, Whitehouse MR, Blom AW. . Re-infection outcomes following one- and two-stage surgical revision of infected hip prosthesis: a systematic review and meta-analysis. 2015;10(9):3-14

If you decide the patient has prosthetic joint infection, ..

2. Masters JPM, Smith NA, Foguet P. . A systematic review of the evidence for single and two-stage revision of infected knee replacement. 2013;14:222

4. Kunutsor SK, Whitehouse MR, Lenguerrand E. . Re-infection outcomes following one- and two-stage surgical revision of infected knee prosthesis: a systematic review and meta-analysis. 2016;11(3):1-15


SUMMARY Prosthetic joint infection ..

Outcome of antibiotic suppressive therapy (n=21) subdivided in several parameters; the affected joint (A), the indication for the prosthesis / underlying condition (B), the type of prosthesis (C) and the causative pathogen / micro-organism for the prosthetic joint infection (PJI) (D). The definition of successful treatment and failed treatment is descripted in the text.

A penile prosthesis infection can initially ..

This is the most devastating complication and is fortunately uncommon (1 – 2% of patients). If infection cannot be eradicated by antibiotics, removal of the components may be required. Infection can occur at any time but often appears some time after the hip surgery. The incidence of infection is increased in patients with rheumatoid arthritis, an existing infection, obesity, diabetes, alcoholism and those patients who are taking immunosuppressive drugs and steroids.

Prosthetic Joint Infection | Bone and Spine

Definition of failed outcome: 1 surgical intervention needed, 2 death due to persistent prosthetic joint infection, 3 persistent pain. RA: rheumatoid arthritis.

Spacer for Prosthetic Joint Infection

The 'regular' antibiotic treatment, the type of AST, the reported side effects and whether these side effects led to a change in antibiotic treatment or dose adjustments, are shown in Table . During the first chosen AST regime, nearly half of the patients reported side effects (43%), which led to a change in treatment in almost all of these patients, from which 50% was a dose adjustment and 50% a change in antibiotic treatment. On the second AST regime, only 3 out of 8 patients reported side effects. None of these 3 led to dose adjustments or a change in the antibiotic regime. Reported side effects were equal between the failed and successful treatment group. Overall, clindamycin was best tolerated; side effects were reported in only 2 out of 7 patients. Loss of appetite improved in one patient after the dose was adjusted to 300 mg TID. Minocycline was the least tolerated drug. Side effects were reported in 4 out of 6 patients, and led to a change of treatment or dose adjustment in all of these patients.

US Navy "smart" prosthetics monitor for signs of infection

The choice for the type of AST was based on the cultured micro-organism(s) and its susceptibility pattern(s), and the expected (long-term) side effects. The antibiotic treatment was advised by the involved medical microbiologist and/or infectiologist. If micro-organisms were considered as a contaminant and were not covered by the chosen antibiotic treatment, this was reported. Side effects of antibiotic treatment mentioned by patients during outpatient clinic visits were collected and noted whether these side effects led to dose adjustments, switch of therapy and/or discontinuation of treatment.