Every prostaglandin contains ..

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Prostaglandins and the Reproductive Cycle | GLOWM

N2 - The effect of progesterone and prostaglandin F2α on cytotoxic activity of lymphocytes was investigated. Thirty-three pregnant women with a clinical diagnosis of threatened premature labour were treated with the prostaglandin synthesis inhibitor acetylsalicyclic acid (2.7 gm/day) for 1 week. Cytotoxic activity of the lymphocytes significantly decreased while their progesterone binding capacity increased by the end of the treatment. Ten healthy pregnant women received a single 15 mg dose of prostaglandin F2α for pregnancy termination. One day after prostaglandin administration lymphocytes showed significantly higher cytotoxic activity and lower progesterone binding capacity than before. Lymphocytes of 44 healthy nonpregnant volunteers were preincubated with prostaglandin F2α and/or progesterone. Prostaglandin F2α (8 nmole) significantly decreased cytotoxic activity of 4 x 106 lymphocytes. In the presence of progesterone prostaglandin F2α failed to stimulate lymphocytes.

The rate-limiting enzyme for prostaglandins synthesis in some ..

The effect of progesterone and prostaglandin F2α on cytotoxic activity of lymphocytes was investigated. Thirty-three pregnant women with a clinical diagnosis of threatened premature labour were treated with the prostaglandin synthesis inhibitor acetylsalicyclic acid (2.7 gm/day) for 1 week. Cytotoxic activity of the lymphocytes significantly decreased while their progesterone binding capacity increased by the end of the treatment. Ten healthy pregnant women received a single 15 mg dose of prostaglandin F2α for pregnancy termination. One day after prostaglandin administration lymphocytes showed significantly higher cytotoxic activity and lower progesterone binding capacity than before. Lymphocytes of 44 healthy nonpregnant volunteers were preincubated with prostaglandin F2α and/or progesterone. Prostaglandin F2α (8 nmole) significantly decreased cytotoxic activity of 4 x 106 lymphocytes. In the presence of progesterone prostaglandin F2α failed to stimulate lymphocytes.

AB - The effect of progesterone and prostaglandin F2α on cytotoxic activity of lymphocytes was investigated. Thirty-three pregnant women with a clinical diagnosis of threatened premature labour were treated with the prostaglandin synthesis inhibitor acetylsalicyclic acid (2.7 gm/day) for 1 week. Cytotoxic activity of the lymphocytes significantly decreased while their progesterone binding capacity increased by the end of the treatment. Ten healthy pregnant women received a single 15 mg dose of prostaglandin F2α for pregnancy termination. One day after prostaglandin administration lymphocytes showed significantly higher cytotoxic activity and lower progesterone binding capacity than before. Lymphocytes of 44 healthy nonpregnant volunteers were preincubated with prostaglandin F2α and/or progesterone. Prostaglandin F2α (8 nmole) significantly decreased cytotoxic activity of 4 x 106 lymphocytes. In the presence of progesterone prostaglandin F2α failed to stimulate lymphocytes.