regulation of progesterone biosynthetic process

Main steps of the progesterone biosynthetic pathway have been analyzed in Digitalis.

Incretins modulate progesterone biosynthesis by …

Synthesis and accumulation of the progestogen-type neuropharmacological agents are not related to plasma progesterone concentrations (Concas et al., 1998).

regulation of progesterone biosynthetic processrelationship: positively_regulates:

Progesterone Inhibits Cholesterol Biosynthesis in …

2.2.3 Biochemical parameters 2.2.3.1 Synthesis Progesterone is synthesized from steroid precursors in the gonads, adrenal cortex, and placenta of mammals.

Estrogen and most of the synthetic progestins increase intracellular sodium and water uptake. The effect of this is hypertension. Natural progesterone is a natural diuretic and prevents the cell's uptake of sodium and water, thus preventing hypertension.


4 The Corpus Luteum; 5 Control of Progesterone Biosynthesis ..

At this point, it is important to make the distinction between the natural progesterone that is produced by the body and the synthetic progesterone analogues classified as progestins, such as Provera, Duphaston and Primulut. As you will learn, there is a big difference between the two in their effect in the body, although doctors most often use their names interchangeably. Since natural progesterone is not a patentable product, the pharmaceutical companies have molecularly altered it to produce synthetic progestins commonly used in contraceptives and HRT.

Control of Progesterone Biosynthesis …

As was previously mentioned, it is progesterone that is responsible for maintaining the secretory endometrium which is necessary for the survival of the embryo as well as the developing fetus throughout gestation. It is little realized, however, that progesterone is the mother of all hormones. Progesterone is the important precursor in the biosynthesis of adrenal corticosteroids (hormones that protect against stress) and of all sex hormones (testosterone and estrogen). This means that progesterone has the capacity to be turned into other hormones further down the pathways as and when the body needs them. The point needs to be emphasized that estrogen and testosterone are end metabolic products made from progesterone. Without adequate progesterone, estrogen and testosterone will not be sufficiently available to the body. Besides being a precursor to sex hormones, progesterone also facilitates many other important, intrinsic physiological functions (which will be discussed later).


Control of progesterone biosynthesis in the bovine …

As the popularity of unopposed estrogen therapy waned, new approaches were sought. The focus was also directed away from the false claims of preserving feminine beauty and youthfulness and towards more urgent health matters. The pharmaceutical industry resurrected estrogen replacement therapy with the new 'safe' hormone replacement therapy - a combination of synthetic progesterone and estrogen which would supposedly protect menopausal women not only from cardiovascular disease but also from the ravages of osteoporosis.

Developmental changes in progesterone biosynthesis …

McLean Estradiol-17ß Explanation Biological data Absorption, distribution, and elimination Biotransformation Hydroxylation Conjugation Biochemical parameters Synthesis Mechanism of action Toxicological studies Acute toxicity Short-term studies of toxicity Long-term studies of toxicity and carcinogenicity Genotoxicity Reproductive toxicity Special studies on mechanism of action Observations in humans Therapeutic use Estradiol-related genetic markers of carcinogenicity Progesterone Explanation Biological data Absorption, distribution, and excretion Biotransformation Biochemical parameters Synthesis Mechamism of action Toxicological studies Acute toxicity Short-term studies of toxicity Long-term studies of toxicity and carcinogencity Genotoxicity Reproductive toxicity Observations in humans Testosterone Explanation Biological data Absorption, distribution, and elimination Biotransformation Biochemical parameters Synthesis Mechamism of action Toxicological studies Acute toxicity Short-term studies of toxicity Long-term studies of toxicity and carcinogenicity Genotoxicity Reproductive toxicity Observations in humans Epidemiological studies of women exposed to postmenopausal estrogen therapy and hormonal contraceptives Methods Postmenopausal oestrogen therapy Exposure Human carcinogenicity Breast cancer Endometrial cancer Cervical cancer Ovarian cancer Cancers of the liver and biliary tract Colorectal cancer Cutaneous malignant melanoma Thyroid cancer Summary and conclusions Cardiovascular disease Osteoporosis Overall mortality Hormonal contraceptives Exposure Human carcinogenicity Breast cancer Endometrial cancer Cervical cancer Ovarian cancer Cancers of the liver and biliary tract Colorectal cancer Cutaneous malignant melanoma Thyroid cancer Summary and conclusions Cardiovascular disease Acute myocardial infarct Stroke Venous thromboembolism Overall mortality Meat intake and cancer risk Comments and evaluation Estradiol-17ß Progesterone Testosterone References The purpose of this monograph is to provide a review and summary of the scientific information relative to a toxicological assessment of the safety of three endogenous hormones, estradiol-17ß, progesterone, and testosterone, with emphasis on information published since the review of the Committee at its thirty-second meeting (Annex 1, reference 80).