General procedure for the synthesis of 1,4-dihydropyridines
Selective Indium-Mediated 1,2,4-Pentatrien-3-ylation of Carbonyl Compounds for the Efficient Synthesis of Vinyl Allenols, 2008,
benign procedure for the synthesis of 1,4-dihydropyridines is ..
Synthesis of Azepinoindoles via Rhodium-Catalyzed Formal Aza-[4 + 3] Cycloaddition Reaction of 3-Diazoindolin-2-imines with 1,3-Dienes in One-Pot 2017,
Indium-Mediated 1,2,4,5-Hexatetraen-3-ylation of 4-Acetoxy-2-azetidinones and Their Applications to the Diels-Alder Reactions for the Synthesis of 2-Azetidinone Derivatives, 2008,
and synthesis of 1,4-dihydropyridine ..
On the other hand, 1,4-dihydropyridines (DHP) containing substituted heterocycles on the C4 position, such as Nifedipine,- have shown to reduce the influx of extracellular Ca+2 ions through the L-type potential-dependent calcium channel therefore reducing the hypertension. Arun et al. have demonstrated that Nifedipine was able to vasodilate the contraction of thoracic aorta isolated from diabetic rats induced by the Angiotensin II. The vazodilation of thoractic aorta was concluded to be due to enhanced functional coupling between AT1 receptors and DHP-sensitive L-type calcium channels.
Pyridine synthesis - Organic chemistry
This study describes by new 1, 4-dihydropyridine with triazole derivatives synthesized from cyclization method. Antimicrobial activity of compounds (1-4) out of the compound (4) exert potent antibacterial and antifungal activity, this compound may possible be used as lead compounds for developing new antimicrobial agent. The methodology was previously reported, but target molecules are new, by its use a wide variety of couplet two heterocyclic compounds could be reached in matter of days and its could be used screening for biological activities. The compound (4) has highly active aganist HepG2 (Liver), Hela (Cervical) and MCF-7 cell line. Therefore, we founded some important detail about biological properties of triazole with 1, 4-dihydropyridine derivatives (1-4), this compounds could be beneficial for anticancer drug synthesis.
Quinoline synthesis - Organic chemistry
Antibacterial activity: The compounds (1-4) were screened for . The synthesized compound (4) (MIC: 8 μg mL-1) is highly active than the standard (Ciprofloxacin MIC: 16 μg mL-1) against , the compound (1) has equipotent activity against stain compared to standard ciprofloxacin (MIC: 0.5 μg mL-1). Other compounds are significantly active at concentration 100 μg mL-1 the zones of inhibition (mm) values are summarized in and .
Professor Mauro F. Adamo - Royal College Surgeons in …
5, 5'-[4-(furan-2-yl)-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-diyl] bis(4-amino-4H-1, 2, 4-triazole-3-thiol) (Compound 4): A mixture of compound (3) (0.01 mol, 3.75 g) and hydrazine hydrate (0.02 mol, 0.8 mL) in methanol, it was heated under reflux on water bath for 7 h. It was cooled to room temperature and poured into crushed ice, the obtained solid was filtered, dried and purified by using ethanol. The progress of reaction was monitored by TLC.