of Nrf2 through the regulation of both transcription and ..

Glutathione supplements pills - Ray Sahelian
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Antioxidants - Immune Health: The Role Of Glutathione …

We hypothesized that resveratrol, a polyphenolic phytoalexin, has antioxidant signaling properties by inducing GSH biosynthesis via the activation of Nrf2 and protects lung epithelial cells against CS-mediated oxidative stress.

Mushrooms: A rich source of the antioxidants …
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Research > Team Cell Energetic Metabolism

INTRODUCTION: Cancer is a broad group of various , all involving unregulated cell growth. In cancer, divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also to more distant parts of the body through the or 1. It is fundamentally a disease of failure of regulation of tissue growth.

Curcumin 95% Turmeric Extract Capsules
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Dietary polyphenols represent a group of secondary metabolites which widely occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly derivatives, and/or isomers of flavones, isoflavones, flavonols, catechins, and phenolic acids. Dietary polyphenols exhibit many biologically significant functions, such as protection against oxidative stress, and degenerative diseases. Experimental data indicate that most of these biological actions can be attributed to their intrinsic antioxidant capabilities. Dietary polyphenols may offer an indirect protection by activating endogenous defense systems and by modulating cellular signaling processes such as NF-κB activation, AP-1 DNA binding, glutathione biosynthesis, PI3-kinase/Akt pathway, MAPK proteins (ERK, JNK and P38) activation, and the translocation into the nucleus of Nrf2 [–].

ATP ENER-G: Mitochondria & Energy Support*
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Genistein is the predominant isoflavone in human nutrition, derived mainly from soybeans but also from other legumes, including peas, lentils, or beans. Genistein has chemopreventive properties, and in particular genistein has been shown to inhibit growth of both androgen-dependent and -independent prostate cancer cells in vitro. Several mechanisms have been proposed for genistein anticarcinogenic activity: inhibition of protein-tyrosine kinase, with the result of alleviating the growth of cancer cells by inhibiting PTK-mediated signaling mechanisms; inhibition of topoisomerases I and II and protein histidine kinase with antiproliferative or proapoptotic effects; antioxidant effects, through inhibition of the expression of stress response related genes; inhibition of NF-κB and Akt signaling pathways; the inhibition of angiogenesis; the down regulation of transforming growth factor-beta (TGF-β), and the inhibition of epidermal growth factor (EGF) 12.

Antioxidant Action of Mangrove Polyphenols against …

Apoptosis, or programmed cell death, can be accomplished either through the death-receptor caspase cascades or the mitochondria caspase cascades 16. Apoptosis plays a major role in establishing a natural balance between cell death and cell renewal in mature animals by destroying excess, damaged or abnormal cells. The activation of NF-κB promotes cell survival and proliferation, and down-regulation of NF-κB sensitizes the cells to apoptosis induction. Expression of several NF-κB-regulated genes such as Bcl-2, cIAP, survivin, TRAF have been reported to function by blocking the apoptosis pathway. The higher ratio of Bax/Bcl-2 leads to the cleavage of caspases and that stimulates the induction of apoptosis 17.

Antioxidant Action of Mangrove Polyphenols ..

Dietary polyphenols represent a wide variety of compounds that occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins and phenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis, anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascular protection, improvement of the endothelial function, as well as inhibition of angiogenesis and cell proliferation activity. Most of these biological actions have been attributed to their intrinsic reducing capabilities. They may also offer indirect protection by activating endogenous defense systems and by modulating cellular signaling processes such as nuclear factor-kappa B (NF-κB) activation, activator protein-1(AP-1) DNA binding, glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway, mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated protein kinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocation into the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers the most recent literature on the subject, and describes the biological mechanisms of action and protective effects of dietary polyphenols.