cellulose-iron oxide nanoparticles ..
The role of nanoparticle geometry in tumor targeting has received relatively little attention, although it is important for determining the binding affinity for a target cell. Sailor . systemically optimized tumor targeting by varying the nanomaterial shape (elongated versus spherical), targeting ligand type (cell surface targeting versus extracellular matrix targeting), ligand surface coverage, and attachment chemistry (Figure ) . They prepared two types of tumor-targeting peptides (F3 or CREKA) and conjugated the peptides to magnetic nanoworms (NWs) or magnetic nanospheres (NSs) at varying numbers of targeting peptides and for varying PEG lengths. Intravenous injection of the magnetic nanostructures in the tumor xenograft mice models revealed that the tumor-targeting properties of the NWs were superior to those of the NSs due to multivalent interactions between the elongated NWs and the receptors on the tumor cell surfaces. The smaller neutral CREKA targeting moiety was more effective than the larger positively charged F3 targeting moiety, presumably because multiple copies of the highly cationic F3 caused a large increase in the surface charge on the particles, which facilitated clearance by the MPS-related organs. The most effective number of CREKA peptides was 60 per NW. Above 60 peptides per NW, the blood circulation time decreased. For a given number of peptides bound to the NWs, the presence of a PEG linker facilitated peptide targeting by reducing conformational restriction as well as increasing the residence time of the nanostructures in the blood stream. The short SMCC linker restricted the targeting peptide conformation. These results suggest some design guidelines for the development of targeted multifunctional nanoparticle systems for cancer imaging and therapy.
in some cases iron oxide nanoparticles.
In addition to the physical interactions described above, other noncovalent secondary interactions can stabilize bioconjugation. Adriamycin, such as Dox, may intercalate into the DNA double stranded helix via guanine-cytosine d(CpG) site-specific interactions. The drug-DNA complex is stabilized by electrostatic hydrogen bonds and stacking π-bonding interactions between the electron-deficient quinine-based chromophore and the electron-rich purine or pyrimidine bases . Based on this specific interaction, Jon . designed a CG-rich duplex containing PSMA aptamer-conjugated GNPs and magnetic nanoparticles as a prostate tumor targeting theranostic agent [, ]. They demonstrated that a PSMA aptamer containing an appended (CGA)7 repeating ONT significantly enhanced the Dox-loading capacity compared to the original PSMA aptamer by providing binding sites for at least 6-7 Dox molecules in the extended region, whereas the original PSMA aptamer included only a single Dox molecule binding site. Conjugation of the elongated PSMA aptamer to nanoparticles proceeded by coating the nanoparticles with aptamer-binding ONTs comprising an A10 spacer and a 5'-(TCG)7-3' complementary sequence. Once the PSMA aptamers had been conjugated onto the nanoparticles, several Dox molecules intercalated among the surface-bound CG-rich duplex containing a PSMA aptamer. The resulting nanoparticles displayed prostate-targeted diagnostic and therapeutic abilities when analyzed by CT imaging/MRI or a tumor-bearing animal model.
143. Zhang J, Misra RD. Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response. 2007;3:838-50
magnetic nanoparticles for biomedical applications.
123. Yu MK, Kim D, Lee IH, So JS, Jeong YY, Jon S. Image-Guided Prostate Cancer Therapy Using Aptamer-Functionalized Thermally Cross-Linked Superparamagnetic Iron Oxide Nanoparticles. 2011;7:2241-9
Tuning Properties of Iron Oxide Nanoparticles in …
107. Lee CM, Jeong HJ, Kim EM, Kim DW, Lim ST, Kim HT. . Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo. 2009;62:1440-6
Synthesis of Iron Oxide Nanoparticles with Biological …
106. Jayapaul J, Hodenius M, Arns S, Lederle W, Lammers T, Comba P. . FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells. 2011;32:5863-71
and Fe/iron oxide nanoparticles ..
151. Jain TK, Morales MA, Sahoo SK, Leslie-Pelecky DL, Labhasetwar V. Iron oxide nanoparticles for sustained delivery of anticancer agents. 2005;2:194-205
Fluid Iron Oxide Nanoparticles - Bing images
58. Ling Y, Wei K, Luo Y, Gao X, Zhong S. Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy. 2011;32:7139-50
The precursors used in the synthesis of Fe by using polyol ..
52. Hadjipanayis CG, Machaidze R, Kaluzova M, Wang L, Schuette AJ, Chen H. . EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. 2010;70:6303-12