Polly Matzinger was born in July 21 ..

Dr Matzinger's work (the topic here) is not related with the pharmas, or any drug in particular.
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The Danger model is a theory of how the immune ..

The Danger Model is quite broad, covering topics as diverse as transplantation, maternal/fetal immunity, autoimmunity, cancer treatments, and vaccines, but Matzinger points out that the original model was designed to offer an explanation of how an immune response is triggered and how it ends, but did not offer an explanation of why the immune system responds in different ways to different situations. She has now extended the model to hypothesize that tissues not only send signals alerting the immune system to local damage and stress, but that the tissues also determine the immune response appropriate for that tissue. Before her lab was shut down by the NIAID administrators in April 2013, her lab was working on experiments to test that hypothesis. She is currently seeking collaborations to continue the research.

You use surgery (or its alternatives) and, if you have not other option, chemo, radiation, to confront the immediate danger.
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a new immunologic model was suggested by Polly Matzinger

A student sitting in an immunology class today will likely hear many phrases coined by Matzinger, such as "professional antigen-presenting-cell", "danger signal", or "DAMPs" (damage associated molecular patterns), but will often hear them in the framework of a self-non-self explanation of immunity. Other immunologists have often adapted parts of Matzinger's ideas without adopting the Danger Model as a theoretical framework.

Gallucci S and Matzinger P (2001) Danger signals: SOS to the immune system. Current Opinion in Immunology 13: 114–119.
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The documentary is notable for incorporating animation, photomicrography, and numerous scenes from old Hollywood films and stock footage, including numerous Busby Berkley choreographed dance scenes.

Matzinger P (1994) Tolerance, danger, and the extended family. Annual Review of Immunology 12: 991–1045.
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Diabetes, Inflammation, and the Danger Hypothesis

In 1989, drawing on the ideas of , proposed that the old immunological paradigm had reached the limitsof its usefulness—or, as he described it, the of the increase in knowledge whichit had brought. Janeway argued that the innate immune system wasthe real gatekeeper of whether the immune system responded or didnot respond. He also argued that the innate immune system usedancient pattern-recognition receptors to make these decisions -recognizing a byits unchanging characteristics.

Diabetes And The Danger Hypothesis

Seong SY and Matzinger P (2004) Hydrophobicity: an ancient damage‐associated molecular pattern that initiates innate immune responses. Nature Reviews Immunology 4: 469–478.

This hypothesis was put forward by Polly Matzinger in 1994

The Danger Model has not won universal acceptance. Someimmunologists, following Janeway's ideas more directly, believethat the immune response is mainly fueled by innateevolutionarily-conserved "pattern recognition receptors" whichrecognize patterns expressed by microbes such as bacteria, and donot see cell death in the absence of pathogens as a primary driverof immune response. These ideas however, do not explain how theimmune system rejects transplants (most well-done transplants arenot covered in bacteria), or tumors, or induce .

Polly Matzinger | Wiki | Everipedia

Matzinger argues that the idea of DAMPs may explain why s seem to respond both to external and endogenous signals (while acknowledging controversy over this issue). By emphasizing her theory that the tissues drive the nature of the immune response (i.e., the "what type" rather than the "whether" of immune response), Matzinger describes a dynamic immune system with complex webs of signalling, rather than an immune system that can be explained by a simple and easily reducible set of molecular signals that initiate response, or by a small set of cells (e.g., regulatory s) which shut it down.

Tumors. Polly Matzinger. Danger-based Immunology course …

The immune system will be the ultimate response to cancer, as it is daily for all those who don't develop cancer.
If you read Matzinger's 1996 article, "Is cancer dangerous to the immune system?", you will see that her answer to that is 'no' --meaning, has to make cancer dangerous to the immune system, so the response of T-cells gets turned on, and the cancer cells are told to die.

I think we need focus more on finding ways to activate those signals ("death bells", they call it in that documentary; they are part of the healthy immune system).