Effects on the thyroid and adrenal glands in birds
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Synergism with other compounds in birds
b As an insecticide, this compound has the ISO approved name of TDE, and it has been sold under the name Rothane(r); in metabloic studies the same compound has been referred as DDD; as a drug, it is called mitotane.
(1970) measured the activities of glucose-6-phosphate dehydrogenase (G-6-P) and 6-phosphogluconate dehydrogenase(6-P-G) in the liver of Japanese quail fed diets containing low levelsof p,p' -DDT or a number of saturated and unsaturated analogues of p,p' -DDT.
An increase in temperature decreases the toxicity ofDDT to fish.
The compound's structure permits several different isomericforms, such as o,p' -DDT (1-chloro-2-[2,2,2-trichloro-1-(4-chloro-phenyl) ethyl] benzene).
The behaviour of fish is influenced by DDT.
In contrast tothe situation in birds, where the main effect of DDT is onreproduction, the main known effect in mammals is to increase themortality of migrating adults.
The toxicity of TDE and DDE has been less studied than that of DDT.
A typical example of technical DDT had the followingconstituents: p,p' -DDT, 77.1%; o,p' -DDT, 14.9%; p,p' -TDE, 0.3%; o,p' -TDE, 0.1%; p,p' -DDE, 4%; o,p' -DDE, 0.1%; and unidentifiedproducts, 3.5%.
The mechanism of shell thinning is not fully understood.
All isomers of the compound DDT are white, crystalline,tasteless, almost odourless solids, with the empirical formulaC14H9Cl5 and a relative molecular mass of 354.5.
The lowest acute dose which killsAmerican big brown bats is 20 mg/kg.
Especially remarkable is the slow metabolism and marked storage of DDTand its metabolite DDE and the rapid metabolism and negligible storageof methoxychlor.
Again, the concentration factors canbe misleading.
KINETICS, METABOLISM, BIOTRANSFORMATION, AND BIOACCUMULATIONAppraisal The physicochemical properties of DDT and its metabolites enable these compounds to be taken up readily by organisms.
Rather, these areexamples from different groups of organisms.
Because of thedifficulties of breeding birds of prey in captivity, most of theexperimental work has been done with insensitive species, which haveoften shown little or no shell thinning.