Type or paste a DOI name into the text box
A. K. Ahuja, J. D. Dorn, A. Caspi, M. J. McMahon, G. Dagnelie, L. Dacruz, P. Stanga, M. S. Humayun, R. J. Greenberg, and Argus II Study Group. Blind subjects implanted with the argus ii retinal prosthesis are able to improve performance in a spatial-motor task. , 95(4):539–543, 2011.
05/10/2006 · Original Article
Magill, K.L. (2016). Retinal prosthesis implantation for retinitis pigmentosa: Patient and provider perspectives. Presented at the Association of Perioperative Nurses, local chapter 2304, Ann Arbor, MI
Retinal degenerative diseases resulting in the progressive loss of photoreceptors are the leading cause of incurable blindness today . Retinal prostheses are designed to reintroduce visual information into the neural system by stimulating the surviving retinal neurons electrically. Several such systems are already in clinical trials, and more advanced technologies are being developed. This review summarizes various approaches to retinal implants, and discusses the challenges and perspectives associated with electronic restoration of sight.
Boston Retinal Implant Project :: The Team
Retinal stimulation with high spatial resolution requires close proximity of electrodes to target cells. This study examines the effects of material coatings and 3-dimensional geometries of subretinal prostheses on their integration with the retina. A trans-scleral implantation technique was developed to place microfabricated structures in the subretinal space of RCS rats. The effect of three coatings (silicon oxide, iridium oxide and parylene) and three geometries (flat, pillars and chambers) on the retinal integration was compared using passive implants. Retinal morphology was evaluated histologically 6 weeks after implantation. For 3-dimensional implants the retinal cell phenotype was also evaluated using Computational Molecular Phenotyping. Flat implants coated with parylene and iridium oxide were generally well tolerated in the subretinal space, inducing only a mild gliotic response. However, silicon-oxide coatings induced the formation of a significant fibrotic seal around the implants. Glial proliferation was observed at the base of the pillar electrode arrays and inside the chambers. The non-traumatic penetration of pillar tips into the retina provided uniform and stable proximity to the inner nuclear layer. Retinal cells migrated into chambers with apertures larger than 10 mum. Both pillars and chambers achieved better proximity to the inner retinal cells than flat implants. However, isolation of retinal cells inside the chamber arrays is likely to affect their long-term viability. Pillars demonstrated minimal alteration of the inner retinal architecture, and thus appear to be the most promising approach for maintaining close proximity between the retinal prosthetic electrodes and target neurons.
Biocompatibility of subretinal materials in Yucatan pigs.
A. C. Ho, M. S. Humayun, J. D. Dorn, L. da Cruz, G. Dagnelie, J. Handa, P. O. Barale, J. A. Sahel, P. E. Stanga, F. Hafezi, A. B. Safran, J. Salzmann, A. Santos, D. Birch, R. Spencer, A. V. Cideciyan, E. de Juan, J. L. Duncan, D. Eliott, A. Fawzi, L. C. Olmos de Koo, G. C. Brown, J. A. Haller, C. D. Regillo, L. V. Del Priore, A. Arditi, D. R. Geruschat, R. J. Greenberg, and I. I. Study Group Argus. Long-term results from an epiretinal prosthesis to restore sight to the blind. , 122(8):1547–54, 2015.
of the most fundamental aspects of neural ..
A Newer Retinal Prosthesis
A type of retinal implant for people with central vision loss may also be available soon from the Boston Retinal Implant Project. The device is similar to the Argus II prosthesis for people with more severe blindness.