Parallel Synthesis with PolyBLOCK

The SynthArray Reactor System - Parallel Synthesis for Medicinal Chemists

Ammonia synthesis reactor having parallel feed ..

Designed for customization To meet individual requirements, it can be equipped with vortexers, hotplates, cooling plates, stirrers, reactor blocks, incubators or other modules from our extensive range of tools. The unique software allows the customer to even integrate his own modules. For special applications we offer the service of integration of custom module

Parallel synthesis laboratory reactor | Laboratory Talk

Digital syringe pumps enable exact dispensing of all reactants with microliter precision. Optimal mixing of the reactants is provided by a variable speed vortex mixer. This guarantees the best synthesis results in terms of yield and purity while minimizing waste and costs. The modular construction offers the greatest flexibility of reaction vessels and storage containers for amino acids and reagents. Different reactor blocks with 24, 48 or 96 positions allow for parallel synthesis of peptides in a range from 1–300 μmol in each reaction vessel. The Syro I system is configured with one reactor block and the Syro II can be configured with two reactor blocks for maximum throughput and productivity.

Syro XP software controls the instrument functions and calculates all amounts and volumes of amino acids and reagents required. Each cycle of the synthesis can receive a completely different protocol. This flexibility allows not only single or multiple couplings, but also complete freedom in the choice of coupling strategies within any synthesis cycle.

Preactivation of the amino acids can be performed for all the synthesis cycles or just for individual ones. The amino acids can be activated in parallel or individually directly prior to their distribution.

The Tip Synthesis option is designed for applications that require large numbers of peptides in small quantities (1–5 μmol). Each Tip Synthesis Module can be used to synthesize up to 96 peptides at a time. Each peptide is synthesized in a 0.4 ml tip with PE frit where accurate dispensing of reagents is essential. The Syro I system can accommodate 1 Tip Synthesis Module, and the Syro II system can accommodate 3–6 modules, allowing up to 576 peptides to be made at the same time.

Syro I is equipped with one type-U reactor block that can accept 2, 5 and 10 ml reactors. An infinitely variable vortexer guarantees an optimal mixing of the reactants.

Digital injection pumps enable dosing with microliter precision and user-friendly software allows all technical possibilities of the robot to be easily implemented.

The modular construction offers great flexibility with respect to the number and size of the storage and reaction containers. Optionally, all storage containers for reagents and reactors can be equipped with the capability to work under inert gas.

The FT reactor system meters up to 100 slpm (3.5 scfm) per bed of clean, pressure-regulated syngas through a preheater and then into a set of downflow, parallel-packed shell-and-tube reactor beds.


Symyx Unveils New Parallel Fixed Bed Reactor

Inert gas control can be provided for reactors and reagents. Inert gas automatically can be added or drawn if reagent is aspirated or delivered to a reactor or reservoir. Special chemically inert septa for reactors and reagent bottles have been developed for Sophas. A safe, non reactive reflux unit, which uses gas cooling, can be provided as an option.

Parallel Chemistry Using Syrris Batch Chemistry Products

We have designed and fabricated a microfluidic reactor array device for massively parallel in-situ synthesis of oligonucleotides (oDNA). The device is made of glass anodically bonded to silicon consisting of three level features: microreactors, microchannels and through inlet/outlet holes. Main challenges in the design of this device include preventing diffusion of photogenerated reagents upon activation and achieving uniform reagent flow through thousands of parallel reactors. The device embodies a simple and effective dynamic isolation mechanism which prevents the intermixing of active reagents between discrete microreactors. Depending on the design parameters, it is possible to achieve uniform flow and synthesis reaction in all of the reactors by proper design of the microreactors and the microchannels. We demonstrated the use of this device on a solution-based, light-directed parallel in-situ oDNA synthesis. We were able to synthesize long oDNA, up to 120 mers at stepwise yield of 98 %. The quality of our microfluidic oDNA microarray including sensitivity, signal noise, specificity, spot variation and accuracy was characterized. Our microfluidic reactor array devices show a great potential for genomics and proteomics researches.

High pressure parallel reactor with individually ..

Solvents and reagents are distributed by the four independently operated 2- or 3-channel probes. Each probe is connected to 2 precision syringe pumps. As the needles provide variable spacing from 8 to 38mm Sophas-Cat can handle any format of reactor blocks and racks. Two liquids can be delivered at the same time through parallel channels in the probe, while the third channel can provide vacuum or gas. For special purposes, each Z-rack can be equipped with a different probe (piercing probe, multi channel probe, filtration probe, spraying probe etc.). The
functions of the probes are controlled by the WinSophas software.

Parallel Micro High Pressure Reactor Customize.

The microarray synthesizer consists of projection optics, a reactor assembly, a reagent manifold, and a computer control system shown in . A mercury arc lamp was used as the light source. A digital micromirror device (DMD, Texas Instruments) was used to generate light patterns projected through a projection lens onto the surface of microfluidic reactor array chip housed in a flow-through cartridge. A beam splitter and a CCD video camera (SONY) were used to assist projector-microarray plate alignment. The cartridge made from 316-stainless steel was connected to a commercial DNA/RNA synthesizer (Expedite 8909, PerSeptive) which served as a reagent manifold. Computer software, written in C++, was developed in-house to generate light patterns based on predetermined oDNA chip layout.