Organic Syntheses - Official Site
Research in organic chemistry at MIT takes place in new, state-of-the-art laboratories in the recently reconstructed Dreyfus Chemistry Building.
Org. Chem. Res - Organic Chemistry Research
Our research utilizes the basic principles in chemistry and material science to explore the potentials of π-conjugated materials and polymer composites for flexible and printed electronics, aiming to provide solutions for a sustainable future with clean energy, safe environment and healthy life. The ongoing research is highly interdisciplinary and collaborative, covering various aspects of organic and polymer synthesis, physical characterization and device fabrication with a central theme of establishing relationships between molecular design, synthetic methodology, materials processing and device performance. To transform laboratory ideas into viable technologies that can positively impact our society is also aligned with our interest.
Research in organic chemistry at MIT addresses a broad spectrum of important problems of current interest and includes investigations at the frontier of bioorganic chemistry, organic synthesis, and materials science. Specific areas of research include protein glycosylation and protein design, chemosensors, continuous flow synthesis, liquid crystals, supramolecular catalysis, the design of new organometallic reagents and catalysts, the invention of new methods for asymmetric catalysis, engineering and pharmaceutical manufacturing, and the development of new strategies for the total synthesis of a wide array of biologically important natural products. A central theme in many projects is the study of structure-reactivity relationships of biological, organic, and organometallic molecules. Much of the current research in the department takes place at the interface of organic chemistry with other areas such as biology, medicine, materials science, and nanotechnology.
Organic Synthesis | Max-Planck-Institut für Kohlenforschung
Professor Jean Chmielewski’s research is at the interface of organic chemistry and biology. Her research group designs and synthesizes novel therapies for diseases, such as bacterial infections, HIV and malaria, and also develops unique biomaterials for regenerative medicine and tissue engineering applications. Graduate students in her group gain expertise in all aspects of the synthesis and testing of their designed agents.
Research & Reviews, Medicinal and Organic Chemistry, Open Access
Total synthesis. Research is focused on exploring strategies for the efficient construction of target compounds. In many cases, judicious selection from the existing ‘toolbox’ of organic transformations is key, but at times novel transformations need to be developed to address a particular structural feature.
Proline Derivatives in Organic Synthesis
The Inorganic Syntheses series is NOT a repository of primary research data, nor is it the place to report new syntheses. It is expected that all syntheses accepted for publication will have already appeared in the primary, peer-reviewed research literature. Thus those syntheses that are found to be widely used by the scientific community or provide a new synthetic entry to a broad range of compounds are most desired for the series. The series offers authors the chance to lay out intricacies of synthesis and purification in greater detail than possible in the original literature, as well as to provide updates of a tried-and-true synthesis.
Homepage – Bode Research Group | ETH Zurich
Research in the Ritter group focuses on the development of novel reaction chemistry. We seek to discover molecular structure and reactivity that can contribute to interdisciplinary solutions for challenges in science. The lab focuses on synthetic organic and organometallic chemistry, complex molecule synthesis, and mechanistic studies to develop practical access to molecules of interest in catalysis, medicine, and materials.
Homepage – Carreira Research Group | ETH Zurich
Many of the most useful synthetic molecules, including numerous pharmaceuticals, contain fluorine due to the desirable unique properties of fluorinated molecules. Carbon–fluorine bond formation is a challenging chemical transformation, especially in the context of general, functional group-tolerant late-stage fluorination of arenes. Our approach to carbon–fluorine bond formation is based on the use of high-valent transition metal fluorides via oxidation of aryl transition metal complexes with electrophilic fluorination reagents. A long-term goal of our research is the development of new methods for the synthesis of small-molecule tracers for positron emission tomography (PET), a powerful imaging technique to study biological processes in vivo. The conceptual advance of our approach is the implementation of new organometallic, organic, and inorganic chemical reactivity as solutions to challenges of interest to the biomedical community. Ultimately, we envision engaging in translational research through new and existing collaborations with physicians and imaging experts to affect the broadest possible impact of our science.
Carbon–fluorine bond formation via reductive elimination is a rare process. We have reported the first isolation of a high-valent palladium fluoride, which can undergo carbon–fluorine reductive elimination. Our work describes the first reductive elimination of an aryl fluoride from a transition metal complex. We identified that C–F reductive elimination proceeds efficiently from aryl Pd(IV) fluoride complexes, stabilized by pyridyl-sulfonamide ancillary ligands. We propose that the pyridyl-sulfonamide ligand plays a crucial role for facile and efficient C–F bond formation.