Fieser, L. F. 2003. 1,2-Naphthoquinone. Organic Syntheses. 68.

“Synthesis of Two Naphthoquinone Antibiotics Pentalongin and Psychorubrin.”  11: 1881–1883.

Synthesis of 1,4-Naphthoquinone by Oxidation of 1-Naphthylamine[J].

SUBSTANCE: light-sensitive photographic material consists of a substrate saturated with a solution of light-sensitive substances in form of successively deposited derivatives of 2-amino-1,4-naphthoquinon-2-amino-(3'-acetoxyphenyl)-3-piperdino-1,4-naphthoquinone (I) and a quaternary salt of 4-(1,4-naphthoquinoyl-2-)-1,1'-dimethylpiperazonium iodide (II).

FIELD: organic chemistry, organic synthesis, chemical technology.

SUBSTANCE: invention relates to a method of producing 2-methyl-1,4-naphthoquinone (menadione, vitamin K3) which is widely used as a preparation for improving blood clotting. The method involves oxidation of 2-methylnaphthalene-containing material with hexavalent chromium compounds in an acidic medium. The 2-methylnaphthalene-containing material used is a methylnaphthalene fraction sampled in temperature interval 235-245�C with distillation of stillage bottoms formed when producing naphthalene from the naphthalene fraction of coal tar.

SUBSTANCE: invention relates to a method for synthesis of 2-methyl-1,4-naphthoquinone (menadione, vitamin K3) that is used broadly in medicinal practice and animal husbandry. Method for synthesis of 2-methyl-1,4-naphthoquinone involves oxidation of 2-methyl-1-naphthol with oxygen or oxygen-containing gas in medium of a low-polar or nonpolar organic solvent or in 2-methyl-1-naphthol melt at intensive stirring, under pressure 1 atm, not less, and temperature 20°C, not less. Method provides simplifying technology and preparing the end product of high purity and high yield.


Naphthoquinone biosynthesis in higher plants. I. …

Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University

1,4-Naphthoquinone for synthesis. CAS 130-15-4, …

AB - Monodispersed and highly stable gold nanoparticles with a diameter between 8 and 9nm were synthesized in a weakly alkaline medium by chemical reduction of AuCl4 - using 5-hydroxyl-1,4-naphthoquinone, and stabilized by the simultaneously formed poly(hydroxyl-1,4-naphthoquinone). The electrochemical properties of the resultant poly(hydroxyl-1,4-naphthoquinone) stabilized gold nanoparticles (AuNQ NPs) and its electrocatalytic activity for glucose oxidation in alkaline media were then investigated using a range of techniques, including dc cyclic, rotating disk electrode and Fourier transformed large amplitude ac voltammetry. The results demonstrate that these AuNQ NP modified electrodes exhibit excellent catalytic activity toward glucose oxidation in the potential region where the premonolayer oxidation process occurs. The overall catalytic glucose oxidation process was found to be mass transport controlled under the experimental conditions employed, allowing measurements to be conducted with a high reproducibility. The AuNQ NP modified electrodes showed a high sensitivity of 183?AmM-1cm-2 with a wide linear dynamic range of 0.5-50mM and a detection limit of 61?M. However, despite its excellent tolerance toward ascorbic acid, significant interference from uric acid was found with this AuNQ NP modified electrode.

Synthesis of 1,2-Naphthoquinone - Chempedia - …

Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University

Preparation of 1,4-naphthoquinone

N2 - Monodispersed and highly stable gold nanoparticles with a diameter between 8 and 9nm were synthesized in a weakly alkaline medium by chemical reduction of AuCl4 - using 5-hydroxyl-1,4-naphthoquinone, and stabilized by the simultaneously formed poly(hydroxyl-1,4-naphthoquinone). The electrochemical properties of the resultant poly(hydroxyl-1,4-naphthoquinone) stabilized gold nanoparticles (AuNQ NPs) and its electrocatalytic activity for glucose oxidation in alkaline media were then investigated using a range of techniques, including dc cyclic, rotating disk electrode and Fourier transformed large amplitude ac voltammetry. The results demonstrate that these AuNQ NP modified electrodes exhibit excellent catalytic activity toward glucose oxidation in the potential region where the premonolayer oxidation process occurs. The overall catalytic glucose oxidation process was found to be mass transport controlled under the experimental conditions employed, allowing measurements to be conducted with a high reproducibility. The AuNQ NP modified electrodes showed a high sensitivity of 183?AmM-1cm-2 with a wide linear dynamic range of 0.5-50mM and a detection limit of 61?M. However, despite its excellent tolerance toward ascorbic acid, significant interference from uric acid was found with this AuNQ NP modified electrode.