Gold nanorods: Synthesis, characterization and applications

 79. Li WJ, Szoka FC. Lipid-based nanoparticles for nucleic acid delivery.  2007;3(24):438-449
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and precise control of gold nanorod ..

113. Lavertu M, Methot S, Tran-Khanh N, Buschmann MD. High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation. 2006;27(27):4815-4824

7. Zhang Z, Wang J, Chen C. Gold nanorods based platforms for light-mediated theranostics.  2013;3:223-38
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Sonoelectrochemical Synthesis of Nanoparticles ..

Further investigations to estimate the potency of the AuNR-dPGS were performed with a well-established murine arthritis model that selectively triggered rheumatoid arthritis in the left injected limb. Figure compares transverse images of two representative sample animals that exhibited moderate arthritis (stage 2 using clinical criteria) in their left ankle 4 h after intravenous injection with gold nanorods bearing either PEG or dPGS. (3D models of the lower part of the animals injected with AuNR-dPGS and AuNR-PEG can be found in supplementary movies). From the observed images acquired at the maximum absorbance wavelength of the gold nanorods (800 nm, Figure A and D), no molecular information can be extracted because they depict both nanoparticle and blood signal. Spectral unmixing depicted in Figure B and E was done to identify and determine the exact location and accumulation of the nanoparticles in the joint. The same processing technique can be applied to blood, in the form of oxygenated hemoglobin, to yield a vasculature map of the region of interest and is presented in panels Figure C and F.

3. Manohar S. Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats.  2011;6:389-400
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In order to test the efficiency of AuNR-dPGS as a L-selectin inhibitor under more physiological conditions, the nanorods were applied in a cellular based flow chamber assay (Figure B) [,]. Therefore, L-selectin transfected K562 cells were passed through a PSGL-1-coated flow channel under a constant shear stress of 1 dyn/cm². The number of rolling cells (flux) of the untreated cells was set to 100%. The flux of the treated cells (preincubated with AuNR-dPGS and AuNR-PEG) was calculated as a percentage flux of the control (representative movies are provided in the Supplementary Material). Figure B confirms a strong binding of AuNR-dPGS to the cells with an IC50 value of 9 nM. The nearly 10-fold higher IC50 value compared to the SPR measurements is due to the much higher concentration of L-selectin presented on the cells in comparison to the gold nanoparticles in the SPR assay.

42. Bhunia SK, Saha A, Maity AR, Ray SC, Jana NR. Carbon Nanoparticle-based Fluorescent Bioimaging Probes.  2013;3:1473
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Seed-Mediated Synthesis of Gold Nanorods: Role of the …

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“ A Hollow Titanium Oxynitride Nanorod Array for an Electrode ..

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37. Chen Y-S, Frey W, Kim S, Homan K, Kruizinga P, Sokolov K. . Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy. 2010;18:8867-78

Carbon/ZnO nanorods composites templated by TEMPO …

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the synthesis of stable nanogold/nanosilver, ..

38. Tian Q, Hu J, Zhu Y, Zou R, Chen Z, Yang S. . Sub-10 nm Fe3O4@ Cu2-x S Core-Shell Nanoparticles for Dual-Modal Imaging and Photothermal Therapy. 2013;135:8571-7

10.1021/nl050788p - ACS Publications Home Page

31. Yang K, Hu L, Ma X, Ye S, Cheng L, Shi X. . Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. 2012;24:1868-72