Book Review: Microwaves in Organic Synthesis - Andre …
Dr. Manoj B. Gawande received his Ph.D. degree in Chemistry in 2008 from Institute of Chemical Technology, Mumbai, India. After several research stays in Germany, South Korea, Portugal, and England, he recently worked as a Visiting Professor at CBC-SPMS, Nanyang Technological University, Singapore. Presently, he is senior researcher at RCPTM, Palacky University, Olomouc, Czech Republic. His research interests are nanocatalysis, design of nanocatalysts, and their applications in greener organic synthesis; he has published over 50 scientific papers.
Microwave Effects in Organic Synthesis: Myth or Reality
In the course of studies on green chemistry one of our goals has been to redesign conventional and time honoured synthetic methods and make them more eco-friendly and consistent with higher atom economy (i.e., less chemical waste). We have now come to the conclusion that the traditional procedures for many reactions are inefficient and involve unnecessary steps. Heating under reflux for several hours is logical for endothermic reactions. For exothermic reactions, however, such energy input would be superfluous.
In recent years, multi-component reactions have attracted the attention of organic chemists because they are more efficient and cost effective. Further, these reactions csan be carried out without isolation of the intermediates (One pot and one step synthesis) and avoid the protection deprotection strategies in the synthesis as well as time consuming purification processes. It is well known that Biginelli reaction is an acid catalyzed versatile one pot multi-component reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H)-one / thione derivatives. The reaction occurs via formation of metal-enolate ion pairs and metal-N-acylimine intermediates which govern the overall progress of Biginelli reaction. The stabilization of N-acylium intermediate by the cation of the catalyst is the exact mechanism involved in this reaction.65-67
Microwave Methods in Organic Synthesis ..
In the early days of microwave synthesis, household microwave ovens were used in chemical laboratories. Although nowadays dedicated instrumentation is available, there are still chemists who use kitchen microwave ovens for scientific purposes. However, most major scientific journals no longer accept manuscripts wherein domestic ovens have been described as heating sources, since there are serious scientific and safety-related arguments to be made for using dedicated instrumentation.
Microwave Synthesis | Organic Chemistry Resources …
ABSTRACT: The objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities. Highly efficient and simple methods complying with principle of Green chemistry have been described in this manuscript for the synthesis with competent yields. As part of current studies, we here in report economical practical techniques like- microwave synthesis, mortal-pastel method (mechanochemistry) and by application of green solvents. On completion of reaction the products were characterized by IR, NMR and Mass Spectra. These methods are more convenient and reactions can be carried out in higher yield (80-96%), shorter reaction time (3-30 min) and milder conditions, without generation of pollution and safer to analyst.
Microwave in Organic Synthesis - Documents - …
This Account describes the current status of MW-assisted synthesis highlighting the introduction of various prototypes of equipment, classes of organic reactions pursued using nanomaterials, and the synthesis of unique and multifunctional nanomaterials; the ensuing nanomaterials possess zero-dimensional to three-dimensional shapes, such as spherical, hexagonal, nanoprisms, star shapes, and nanorods. The synthesis of well-defined nanomaterials and nanocatalysts is an integral part of nanotechnology and catalysis science, because it is imperative to control their size, shape, and compositional engineering for unique deployment in the field of nanocatalysis and organic synthesis.
Microwaves in Organic Synthesis, 2 Volume Set, ..
In Prof. Gascon’s group you will carry out multi-scale computer simulations to investigate the electronic, structural and dynamical properties of small gold nanoparticles embedded in a monolayer of thiolated ligands. Such levels of molecular detail will allow us to correlate structural properties with spectroscopy analysis. You will learn the fundamentals of various levels of theory, from Molecular Mechanics to Quantum Mechanics. If you are interested in chemistry and computation, this experience will challenge you and broaden your understanding of the importance of computational modeling in today’s scientific endeavors.