The Michael reaction or Michael addition is the nucleophilic ..

Synthesis - Imperial College London

Introduction - Imperial College London

A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)2 complex. The methodology has successfully been employed in the synthesis of ()-Warfarin and another related compounds.

Synthesis and characterization of novel polystyrene-supported TBD catalysts and their use in the Michael addition for the synthesis of Warfarin and its analogues

Synthesis: There are 3 types of Warfarin ..

The usual synthetic route for racemic Warfarin involves a base/acid catalysed Michael condensation reaction of 4-hydroxycoumarin with benzalacetone. These reactants are either refluxed in water for approximately 4-8 hours or refluxed with pyridine which gives a saturated yield. The mechanism is shown below:

03/01/2018 · View This Abstract Online; Enzyme-catalyzed Michael addition for the synthesis of warfarin and its determination via fluorescence quenching of l-tryptophan.

A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)2 complex. The methodology has successfully been employed in the synthesis of ()-Warfarin and another related compounds.

11/05/2012 · Promiscuous enzyme-catalyzed Michael addition: synthesis of warfarin and ..