Enzymatic Synthesis of Magnetic Nanoparticles - MDPI

9 Wet-Phase Synthesis of Typical Magnetic Nanoparticles with Controlled Morphologies 291

Synthesis of Magnetic Nanoparticles Ni0.5Zn0.5Fe2O4 …

The research on superparamagnetic iron oxide nanoparticles (SPIONs) has been growing exponentially over the last several years. The field continues to drive in the direction of biomedical applications, especially molecular therapeutics by exploiting the immense qualities of SPIONs []. This includes the distinctive controllable properties such as size, shape, magnetism, crystallinity and flexibility in fabricating multifunctional SPIONs with fluorescence, targeting ligands, drugs etc, thanks to the advancements in the syntheses and functionalization techniques developed hitherto. There are some excellent synthetic methods in prior arts on the formation of superparamagnetic magnetite (Fe3O4) and maghemite (γ-Fe2O3) SPIONs, with size control, narrow distribution, water solubility and surface functionalization [-]. The co-precipitation method is a conventional synthetic paradigm where Fe(II) and Fe(III) salts are co-precipitated in a basic solution in the presence of coating materials such as polymer or dextran (or its derivatives). Although the resulted iron oxide nanoparticles (NPs) are larger in size (ca. 100 nm) and partially crystalline, the particles are readily water soluble where their surfaces are directly functionalized. Alternatively, thermal decomposition method using precursors such as Fe(CO)5, Fe(Stearate)2, with high boiling solvents (octadecene, benzyl ether) and surfactants/ligands (oleic acid, oleylamine) can be used to synthesize smaller sized hydrophobic SPIONs (5-10 nm). In order to impart the SPIONs with water solubility for biomedical applications, water-oil microemulsion method can be employed as a reaction medium for coating a hydrophilic ligand (e.g. silica, peptides) on the hydrophobic surface.

Synthesis of monosized magnetic-optical AuFe alloy nanoparticles

In recent years, multifunctional nanoparticles (NPs) consisting of either metal (e.g. Au), or magnetic NP (e.g. iron oxide) with other fluorescent components such as quantum dots (QDs) or organic dyes have been emerging as versatile candidate systems for cancer diagnosis, therapy, and macromolecule delivery such as micro ribonucleic acid (microRNA). This review intends to highlight the recent advances in the synthesis and application of multifunctional NPs (mainly iron oxide) in theranostics, an area used to combine therapeutics and diagnostics. The recent applications of NPs in miRNA delivery are also reviewed.

3. Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological application. 2008;108:2064-110

Nanocs - Magnetic Nanoparticles

Magnetism being one of the oldest scientific disciplines has been continuously studied since 6th century BC, which still offers scientific innovations today in realm of nanomagnetism. Iron oxide nanomaterials have been growing excessive importance because of their magnetic characteristics and wide applications. Iron oxides magnetic nanoparticles with appropriate surface chemistry are prepared either by wet chemical method such as colloid chemical or sol-gel methods or by dry processes such as vapour deposition techniques. This review summarizes comparative and brief study of the methods for the preparation of iron oxide magnetic nanoparticles with a control over the size, morphology and the magnetic properties. Applications of microwave irradiation for magnetic particle synthesis are also addressed.

Green Synthesis of Metallic Nanoparticles via ..

56. Jarett BR, Gustafsson B, Kukis DL, Louie AY. Synthesis of 64Cu-labeled magnetic nanoparticles for multimodal imaging. 2008;19:1496-1504

Curing cancer with magnetic nanoparticles and …

67. Sonvico F, Mornet S, Vasseur S, Dubernet C, Jaillard D, Degrouard J, Hoebeke J, Duguet E, Colombo P, Couvreur P. Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: Synthesis, physicochemical characterization, and experiments. 2005;16:1181-8