Biosynthesis of pyrimidines leading to formation of UMP.

Biosynthesis of the pyrimidine ring. Precursors of the ring and numbering of the ring atoms.

Biosynthesis of CTP and dTMP. Abbreviation: THF, tetrahydrofolate.

Effects of inhibitors of RNA and protein synthesis on the subcellular distribution of the eukaryotic translation initiation factor, eIF-5A, and the HIV-1 Rev protein.

However, only one mutant (#370) was used so far to identify the synthetic lethal gene.

Nitrate balance and biosynthesis in the ferret.

Nicotine could contribute to the progression of chronic hypertension by aggravating vasoconstriction either in sympathetic activation or inhibition of prostaglandin synthesis.

During this stage, it was confirmed if the synthetic lethality was specific to

Zhao H, French JB, Fang Y and Benkovic SJ (2013). The purinosome, a multi‐protein complex involved in the de novo biosynthesis of purines in humans. Chemical Communications 49: 4444–4452.

The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.


lethal synthesis - oi - Oxford Index Home - oi

For immunization, five female Special pathogen free (SPF) BALB/c mice (6-8 weeks) per group were immunized subcutaneously (s.c.) with a 50% emulsion of Freund's complete adjuvant containing either 100 μg of conjugated recombinant proteins HBc-VP2(aa141-155) or HBc(aa1-149). Three booster doses in 50% emulsions with Freund's incomplete adjuvant were given at two weekly intervals. The immunized animals were bled at 0, 2, 4, 6, 8,10,12 weeks for the serological tests, and the serum was collected and stored at -80°C.

Lethal synthesis - Oxford Reference

The strain SVL422, containing single mutant was first obtained by crossing the SVL398 and SVL82 strains to generate SVL401 and then SVL401 was crossed with the synthetic lethal mutant strain (SVL338).

Total Synthesis of Polycavernosides A and B, Two Lethal …

If a new chromosomal mutation is produced on a synthetically lethal gene, the plasmid containing the wild-type copy of gene would be then required for survival at 25ºC, generating red colonies (sec

PPT - Lethal Synthesis PowerPoint Presentation - …

No mutagenicity studies have been conducted, however DNA synthesis rates decrease by 40-60% in rats intraperitoneally dosed with 5 mg/kg fluoroacetate. (ACGIH 1991)

Lethal Synthesis definitions - Defined Term

In this screen, we revealed that eIF5A is synthetic lethal with the essential gene which encodes for an Ypt-GTPase involved with secretion, acting in the vesicular trafficking between the endoplasmatic reticulum and the Golgi.