NO synthesis, leptin caused a ..
CONCLUSION: These data demonstrate that, in soleus muscle, leptin per se exerts a direct and acute insulin-like effect, stimulating glucose uptake, glycogen synthesis, lactate formation and glucose oxidation.
Regulation of Catecholamine Synthesis by Leptin
The present study demonstrated the existence of the leptin-specific binding sites that mediate its stimulatory effect on insulin secretion and synthesis in HIT-T 15 cells.">
Hormones may control the regulation of leptin synthesis. When glucocorticoids or cAMP were administered, mRNA and leptin secretion was decreased (20), while insulin and corticosterone increased leptin production in both rodent and human adipose cells (21). Leptin also appears to be under the control of metabolic factors. Fasting markedly reduced mRNA levels, but upon re-feeding, mRNA levels were restored (21).