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Pyridine synthesis - Organic chemistry

Chichibabin Pyridine Synthesis; Chichibabin Reaction;

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Krohnke pyridine synthesis mechanism

Modification of Krohnke pyridine synthesis (Krohnke, 1976) ..

Successful synthesis of Krohnke type pyridines is reported through the. The radical scavenging mechanism is based on the transfer of H-atom from the.

Modification of Krohnke pyridine synthesis 17 has been used for the ..

Pyridine derivatives are an important part of the repertoire in the discovery of new pharmaceuticals and agrochemicals. In this regard, combinatorial chemistry can be a powerful tool. The Kröhnke synthesis of 2,4,6-trisubstituted pyridines is ideal for combinatorial applications, since reactions generally proceed in high yields on solid phase, and three points of diversity can be independently varied. A 220-member Kröhnke pyridine library was prepared on andael using a combined split-mix and parallel strategy affording 55 pools of four members each after cleavage from the resin. The library was analyzed by HPLC and LC/MS that indicated 85% of the pools were of good quality in terms of yield, purity, and members present in similar amounts. Notably, the library was prepared on a large scale (∼15 to 20 mg per member) and in a time/cost efficient manner. The pooling approach facilitated synthesis and should also prove advantageous in biological screening experiments.