Prostaglandins/analysis; Prostaglandins/biosynthesis*

T1 - Inhibition of prostaglandin synthesis and effects of ethanol and pentobarbital in humans

Mechanism of steroid action in inflammation: Inhibition …

Its efficacy appears to be related to induction of glutathione S-transferase enzymes, inhibition of prostaglandin E(2) (PGE(2)) production, or suppression of oxidative DNA adduct (M(1)G) formation.

T1 - Modulation of tumor cell motility by prostaglandins and inhibitors of prostaglandin synthesis

Inhibition of prostaglandin synthesis in intact cells …

These results suggest that the effect of NO on PGs synthesis in LPS-treated macrophage cells is mainly due to the balance of its stimulations of the transcriptional and/or translational expression of PGHS-2 and the inhibition of the induced PGHS-2 activity.

NOC 12 also dose dependently inhibited PG synthesis from exogenous arachidonic acid in those cells.

These results suggest that the 40% ethanol extract of mangosteen has potent inhibitory activities of both histamine release and prostaglandin E2 synthesis.

Accumulating data suggest that the interaction of various enzymes in the Prostaglandin E2 synthetic pathway is complex and tightly regulated.


Inhibition of Prostaglandin Biosynthesis by Corticosteroids

The physiological activation of human platelets was shown to acutely mediates the esterification of free prostaglandins to membrane phospholipids (mainly phosphatidylethanolamine) ().

Prostaglandin Synthesis, Inhibition, ..

Thus, are formed PGD2 (the principal cyclooxygenase product of the mast cells and the nervous system, it inhibits platelet aggregation), PGE2 (produced in near all cell types, elevates cAMP levels, stimulates bone resorption), PGF2a, PGI2 (prostacyclin, characterizes endothelial cells, induces vasodilation and inhibits platelet aggregation), thromboxane A2, TXA2, (was first isolated from thrombocytes or platelets, it has strong platelet-aggregating activity) and even a 17 -carbon hydroxylated fatty acid 12-HHT (12-hydroxyheptadeca-5,8,10-trienoic acid), stimulates prostacyclin production and has chemotactic activity.

Inhibition of Prostaglandin Biosynthesis - …

Arachidonic acid, or AA, is what Series 2 prostaglandins, or the "bad" prostaglandins, are made from.

Series 2 prostaglandins promote platelet aggregation (clot formation); inflammation; sodium retention; and may influence heart disease, blood clots, increased cortisol production, etc..

Inhibition of Prostaglandin Biosynthesis | SpringerLink

This series of prostaglandins relax blood vessels, improve circulation, lower blood pressure, decrease inflammation, improve nerve function, regulate calcium metabolism, improve T-cell function, and lastly, prevent the release of something called "arachidonic acid" from cells.

inhibition of prostaglandins - Traduction française – …

These results suggest that the effect of NO on PGs synthesis in LPS-treated macrophage cells is mainly due to the balance of its stimulations of the transcriptional and/or translational expression of PGHS-2 and the inhibition of the induced PGHS-2 activity.">