Tumor suppressor gene - Wikipedia

We provide a summary of the tumors reported in DM and a hypothesis for a ..

Mathematical Models for Cancer Growth - Chemoth

The fact that certain tumors exhibit a predilection for metastasis to specific organs has been recognized for well over a century now. An extensive body of clinical data and experimental research has confirmed Stephen Paget's original "seed and soil" hypothesis that proposed the organ-preference patterns of tumor metastasis are the product of favorable interactions between metastatic tumor cells (the "seed") and their organ microenvironment (the "soil"). Indeed, many of the first-line therapeutic regimens, currently in use for the treatment of human cancer are designed to target cancer cells (such as chemotherapy) and also to modulate the tumor microenvironment (such as antiangiogenic therapy). While some types of tumors are capable of forming metastases in virtually every organ in the body, the most frequent target organs of metastasis are bone, brain, liver and the lung. In this review, we discuss how tumor-stromal interactions influence metastasis in each of these organs.

This hypothesis is further supported by the occurrence of tuberculosis, metastases and malignant lymphomas in the lymphoid stroma of those tumors.

Desmoid Tumor: Background, Pathophysiology, …

The extraparotid location and multicentric nature of these tumors can be explained by the last-mentioned hypothesis.
Other studies discussed the importance of immunological reactions during the formation of Warthin's tumor.

T1 - The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

N2 - The fact that certain tumors exhibit a predilection for metastasis to specific organs has been recognized for well over a century now. An extensive body of clinical data and experimental research has confirmed Stephen Paget's original "seed and soil" hypothesis that proposed the organ-preference patterns of tumor metastasis are the product of favorable interactions between metastatic tumor cells (the "seed") and their organ microenvironment (the "soil"). Indeed, many of the first-line therapeutic regimens, currently in use for the treatment of human cancer are designed to target cancer cells (such as chemotherapy) and also to modulate the tumor microenvironment (such as antiangiogenic therapy). While some types of tumors are capable of forming metastases in virtually every organ in the body, the most frequent target organs of metastasis are bone, brain, liver and the lung. In this review, we discuss how tumor-stromal interactions influence metastasis in each of these organs.

Hypothesis According to our hypothesis, a tumor cell would be the only one able to respond to the demand to proliferate in the organ of origin.